[3dem] postdoc position: cryo-EM analysis of Ryanodine Receptor complexes in Vancouver, Canada

[Filip Van Petegem]

Dear colleagues,

A postdoctoral position is available to work on ion channel structural
biology in the lab of Filip Van Petegemat the University of British
Columbia (Vancouver, Canada). The project focuses on the regulation and
pathophysiology of Ryanodine Receptors (RyRs) and their associated
proteins. RyRs represent the largest ion channels currently known and are
targets for hundreds of mutations that cause cardiac arrhythmias,
myopathies, and malignant hyperthermia.



The project combines cryo-EM and electrophysiology with various biophysical
methods. For some aspects, X-ray crystallography may be required. Our lab
has steady access to the in-house cryo-EM facility, which houses a Titan
Krios with Falcon IV detector and a 200kV Glacios (Falcon III) for
pre-screening grids, as well as microscopes for negative stain EM.



Minimum requirements for applicants include a PhD in Biochemistry or a
related discipline with extensive experience with one or more structural
biology methods (NMR, X-ray crystallography, or cryo-EM). Direct experience
with membrane proteins is an additional plus.



The lab values diversity and inclusivity, and applicants from all
backgrounds are encouraged to apply. This is an opportunity for people with
a structural biology background to learn electrophysiological methods.



Recent work from the lab includes an investigation of how Ryanodine
Receptors are modulated by small molecules, disease mutations, and
post-translational modification, using cryo-EM, X-ray crystallography,
planar lipid bilayer electrophysiology, and enzyme kinetics.



Recent work on this topic:


Yang et al (2022) *PNAS* 119:e2120416119

Woll et al (2021) *Nature Comm.* 12:807

Ma et al (2020) *Nat Chem Biol*. 16,1246-1254

Haji-Ghassemi et al (2019) *Molecular Cell* 75,1-14


For more information on recent work, see https://urldefense.com/v3/__http://crg.ubc.ca/VanPetegem/__;!!Mih3wA!FHo7wrbS1o4ymVbxh4P8JStBEDxGjjZDREdw_AiCaWTK9-J9W2B9J4U3PBwk5OiB77wic9X4rhiCa5EThOHFw63derJ6Sw$  

The lab is housed within the Life Sciences Centre at UBC (lsi.ubc.ca),
located on the Point Grey campus in Vancouver.


Interested candidates should send a CV, a cover letter showing the
motivation to apply, along with names and contact details for 3 references
to filip.vanpetegem at gmail.com.




-- 
Filip Van Petegem, PhD
Professor, Dept. of Biochemistry and Molecular Biology
The University of British Columbia
2350 Health Sciences Mall - Rm 2.356
Vancouver, V6T 1Z3

phone: +1 604 827 4267
email: filip.vanpetegem at gmail.com
https://urldefense.com/v3/__http://crg.ubc.ca/VanPetegem/__;!!Mih3wA!FHo7wrbS1o4ymVbxh4P8JStBEDxGjjZDREdw_AiCaWTK9-J9W2B9J4U3PBwk5OiB77wic9X4rhiCa5EThOHFw63derJ6Sw$  

Twitter: @FilipPetegem
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20220902/d6d3e02b/attachment.html>