<div dir="ltr"><font face="arial, sans-serif">Dear colleagues,</font><div><font face="arial, sans-serif"><br></font></div><div><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black">A postdoctoral position is available to work on ion channel structural biology in the lab of Filip Van Petegemat the University of British Columbia (Vancouver, Canada). The project focuses on the regulation and pathophysiology of Ryanodine Receptors (RyRs) and their associated proteins. RyRs represent the largest ion channels currently known and are targets for hundreds of mutations that cause cardiac arrhythmias, myopathies, and malignant hyperthermia.</span></font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black">The project combines cryo-EM and electrophysiology with various biophysical methods. For some aspects, X-ray crystallography may be required. Our lab has steady access to the in-house cryo-EM facility, which houses a Titan Krios with Falcon IV detector and a 200kV Glacios (Falcon III) for pre-screening grids, as well as microscopes for negative stain EM. </span></font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black">Minimum requirements for applicants include a PhD in Biochemistry or a related discipline with extensive experience with one or more structural biology methods (NMR, X-ray crystallography, or cryo-EM). Direct experience with membrane proteins is an additional plus.</span></font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black">The lab values diversity and inclusivity, and applicants from all backgrounds are encouraged to apply. This is an opportunity for people with a structural biology background to learn electrophysiological methods.</span></font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black">Recent work from the lab includes an investigation of how Ryanodine Receptors are modulated by small molecules, disease mutations, and post-translational modification, using cryo-EM, X-ray crystallography, planar lipid bilayer electrophysiology, and enzyme kinetics.</span></font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black">Recent work on this topic:</span></font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black"><br></span></font></p><p class="MsoNormal" style="margin:0cm;line-height:13.91px"><font face="arial, sans-serif"><a name="_Hlk73805553"><span lang="EN-US" style="line-height:13.91px;color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Yang et al (2022) <i>PNAS</i> 119:e2120416119</span></a><span lang="EN-US" style="line-height:13.91px;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"></span></font></p><p class="MsoNormal" style="margin:0cm;line-height:13.91px"><font face="arial, sans-serif"><span lang="EN-US" style="line-height:13.91px;color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Woll et al (2021) <i>Nature Comm.</i> 12:807</span><span lang="EN-US" style="line-height:13.91px;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"></span></font></p><p class="MsoNormal" style="margin:0cm;line-height:13.91px"><font face="arial, sans-serif"><a name="_Hlk73805545"><span lang="EN-US" style="line-height:13.91px;color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Ma et al (2020) <i>Nat Chem Biol</i>. 16,1246-1254</span></a><span lang="EN-US" style="line-height:13.91px;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"></span></font></p><p class="MsoNormal" style="margin:0cm;line-height:13.91px"><font face="arial, sans-serif"><span lang="EN-US" style="line-height:13.91px;color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Haji-Ghassemi et al (2019) <i>Molecular Cell</i> 75,1-14</span><span lang="EN-US" style="line-height:13.91px;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"></span></font></p><p class="MsoNormal" style="margin:0cm;line-height:13.91px"><font face="arial, sans-serif"><br></font></p><p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black">For more information on recent work, see </span><span lang="EN-US" style="color:black"><a href="https://urldefense.com/v3/__http://crg.ubc.ca/VanPetegem/__;!!Mih3wA!FHo7wrbS1o4ymVbxh4P8JStBEDxGjjZDREdw_AiCaWTK9-J9W2B9J4U3PBwk5OiB77wic9X4rhiCa5EThOHFw63derJ6Sw$" target="_blank" style="color:blue"><span lang="EN-CA" style="color:black">http://crg.ubc.ca/VanPetegem/</span></a></span><b><span lang="EN-US" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"></span></b></font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black">The lab is housed within the Life Sciences Centre at UBC (<a href="https://urldefense.com/v3/__http://lsi.ubc.ca__;!!Mih3wA!FHo7wrbS1o4ymVbxh4P8JStBEDxGjjZDREdw_AiCaWTK9-J9W2B9J4U3PBwk5OiB77wic9X4rhiCa5EThOHFw61qft5oAg$">lsi.ubc.ca</a>), located on the Point Grey campus in Vancouver.</span></font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><span style="color:black"><font face="arial, sans-serif"><br></font></span></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black">Interested candidates should send a CV, a cover letter showing the motivation to apply, along with names and contact details for 3 references to </span><span lang="EN-US" style="color:black"><a href="mailto:filip.vanpetegem@gmail.com" style="color:blue"><span lang="EN-CA" style="color:black">filip.vanpetegem@gmail.com</span></a></span><span style="color:black">.</span></font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p><font face="arial, sans-serif"><br></font></div><div><br></div>-- <br><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div>Filip Van Petegem, PhD</div><div>Professor, Dept. of Biochemistry and Molecular Biology<br>The University of British Columbia<br>2350 Health Sciences Mall - Rm 2.356<br>Vancouver, V6T 1Z3<br><br>phone: +1 604 827 4267<br>email: <a href="mailto:filip.vanpetegem@gmail.com" target="_blank">filip.vanpetegem@gmail.com</a><br><a href="https://urldefense.com/v3/__http://crg.ubc.ca/VanPetegem/__;!!Mih3wA!FHo7wrbS1o4ymVbxh4P8JStBEDxGjjZDREdw_AiCaWTK9-J9W2B9J4U3PBwk5OiB77wic9X4rhiCa5EThOHFw63derJ6Sw$" target="_blank">http://crg.ubc.ca/VanPetegem/</a></div><div><br></div><div>Twitter: @FilipPetegem</div></div></div></div>