[3dem] Industrial cryo-EM position: Cryo-EM at Pfizer (Groton, CT)

[Han, Seungil]

All,
Pfizer Structural & Molecular Sciences group (Groton, CT) has a new opening for Senior Scientist, cryo-EM (Job ID: 4752640) and the candidate can apply the job in the link below.
Thanks in advance for your interest!
Seungil Han

https://pfizer.wd1.myworkdayjobs.com/PfizerCareers/job/United-States---Connecticut---Groton/Senior-Scientist--CryoEM--Structural---Molecular-Sciences_4752640-1

https://www.linkedin.com/jobs/view/1346718660/


ROLE SUMMARY
We have an open position at the Senior Scientist level for a cryo-EM position in the Structural and Molecular Sciences (SMS) group at our Groton, CT Pfizer Research and Development campus. The SMS group is a multidisciplinary group with established expertise in molecular biology, protein biochemistry, protein mass spectrometry, enzymology, NMR, biophysics, protein X-ray crystallography and cryo-EM. Our mission is to provide integrated molecular insights into drug targets, lead compounds and target-compound & -antibody interactions to advance discovery efforts across multiple therapeutic areas, including Inflammation and Immunology, Vaccines, Biologicals, Cardiovascular and Metabolic Diseases and Rare Diseases.

We are equipped with a Titan Krios microscope with a Gatan K2 Summit direct electron detector, GIF energy filter and Volta Phase Plate for high resolution data collection, a TF20 microscope with a Gatan OneView detector for sample characterization, and a dedicated computer cluster and GPU boxes for data processing and refinement. We have already been successful in application of cryo-EM technology to several Pfizer projects.

As a Senior Scientist, you will have broad experience or familiarity with different aspects of structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and 3-D reconstruction. We are looking for someone who is passionate about the hardware and computing skills associated with EM such as microscope, direct electron detector, sample robot, computer cluster, etc. and their maintenance. Equally important will be your ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams. You will eventually be expected to understand the critical issues and challenges faced by different drug discovery programs within Pfizer and design suitable experimental strategies based on cryo-EM techniques to positively impact drug discovery.

ROLE RESPONSIBILITIES

  *   As part of the EM team, help manage, maintain and develop the facility, supports users, and lead collaborative projects aimed at improving our cryo-EM infrastructure and scientific research program.
  *   Leveraging your cryo-EM expertise, provide consultation and guidance to colleagues from other SMS labs for EM studies and serve as a valuable resource for the entire department.
  *   Independently undertake cryo-EM studies of targets that are of interest to Pfizer. The proposed work will involve all aspects of cryo-EM structure determination including preparation of suitable grids, analysis by negative staining, cryo-EM data collection, class averaging, 3D-reconstruction and refinement.
  *   Deliver novel scientific insights for the design of small molecule ligands as well as biologicals, vaccines and viral capsids for gene therapy.
  *   Establish productive collaborations with other SMS colleagues and form partnerships with colleagues from research units and other departments.
  *   Rapidly advance projects by timely problem solving and crisp decision making.
  *   Clearly communicate with project team members and other Pfizer colleagues.
  *   Consistently record your experimental results in an electronic laboratory notebook and comply with all Pfizer safety policies.

BASIC QUALIFICATIONS

  *   Doctoral degree or equivalent in Biochemistry, Biophysics, Physics, Chemistry or related field.
  *   Postdoctoral training in cryo-EM with 1-3 years of industrial or academic experience.
  *   Proven ability to independently design and conduct state-of-the-art single particle cryo-EM experiments, leading to a strong track record of successful outcomes with publications in top tier journals.
  *   Must be able to thrive and deliver results in a fast paced, dynamic and highly multi-tasking environment.
  *   Broad knowledge in protein characterization, structural biology, biophysics and computational chemistry.
  *   Demonstrated ability to work independently and in teams in an inclusive manner
  *   Proven scientific influence via strong interpersonal and communication skills; passionate about using structural data to influence key scientific decisions. Has the skill and drive to grow into a thought leader.

PREFERRED QUALIFICATIONS

  *   Broad experience or familiarity with different aspects of structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and 3-D reconstruction.
  *   Passionate about the hardware and computing skills associated with EM such as microscope, direct electron detector, sample robot, computer cluster, etc. and their maintenance.
  *   Ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams.



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