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<p class="MsoNormal">All,<o:p></o:p></p>
<p class="MsoNormal">Pfizer Structural & Molecular Sciences group (Groton, CT) has a new opening for Senior Scientist, cryo-EM (Job ID: 4752640) and the candidate can apply the job in the link below.<o:p></o:p></p>
<p class="MsoNormal">Thanks in advance for your interest!<o:p></o:p></p>
<p class="MsoNormal">Seungil Han<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><a href="https://pfizer.wd1.myworkdayjobs.com/PfizerCareers/job/United-States---Connecticut---Groton/Senior-Scientist--CryoEM--Structural---Molecular-Sciences_4752640-1">https://pfizer.wd1.myworkdayjobs.com/PfizerCareers/job/United-States---Connecticut---Groton/Senior-Scientist--CryoEM--Structural---Molecular-Sciences_4752640-1</a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><a href="https://www.linkedin.com/jobs/view/1346718660/">https://www.linkedin.com/jobs/view/1346718660/</a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b><u>ROLE SUMMARY<o:p></o:p></u></b></p>
<p class="MsoNormal">We have an open position at the Senior Scientist level for a cryo-EM position in the Structural and Molecular Sciences (SMS) group at our Groton, CT Pfizer Research and Development campus. The SMS group is a multidisciplinary group with
established expertise in molecular biology, protein biochemistry, protein mass spectrometry, enzymology, NMR, biophysics, protein X-ray crystallography and cryo-EM. Our mission is to provide integrated molecular insights into drug targets, lead compounds and
target-compound & -antibody interactions to advance discovery efforts across multiple therapeutic areas, including Inflammation and Immunology, Vaccines, Biologicals, Cardiovascular and Metabolic Diseases and Rare Diseases.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">We are equipped with a Titan Krios microscope with a Gatan K2 Summit direct electron detector, GIF energy filter and Volta Phase Plate for high resolution data collection, a TF20 microscope with a Gatan OneView detector for sample characterization,
and a dedicated computer cluster and GPU boxes for data processing and refinement. We have already been successful in application of cryo-EM technology to several Pfizer projects.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">As a Senior Scientist, you will have broad experience or familiarity with different aspects of structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and
3-D reconstruction. We are looking for someone who is passionate about the hardware and computing skills associated with EM such as microscope, direct electron detector, sample robot, computer cluster, etc. and their maintenance. Equally important will be
your ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams. You will eventually be expected to understand the critical issues and challenges faced by different drug discovery
programs within Pfizer and design suitable experimental strategies based on cryo-EM techniques to positively impact drug discovery.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b><u>ROLE RESPONSIBILITIES <o:p></o:p></u></b></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="margin-left:-.25in;mso-list:l2 level1 lfo3">As part of the EM team, help manage, maintain and develop the facility, supports users, and lead collaborative projects aimed at improving our cryo-EM infrastructure and scientific research
program.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l2 level1 lfo3">Leveraging your cryo-EM expertise, provide consultation and guidance to colleagues from other SMS labs for EM studies and serve as a valuable resource for the entire department.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l2 level1 lfo3">Independently undertake cryo-EM studies of targets that are of interest to Pfizer. The proposed work will involve all aspects of cryo-EM structure determination including preparation of
suitable grids, analysis by negative staining, cryo-EM data collection, class averaging, 3D-reconstruction and refinement.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l2 level1 lfo3">Deliver novel scientific insights for the design of small molecule ligands as well as biologicals, vaccines and viral capsids for gene therapy.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l2 level1 lfo3">Establish productive collaborations with other SMS colleagues and form partnerships with colleagues from research units and other departments.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l2 level1 lfo3">Rapidly advance projects by timely problem solving and crisp decision making.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l2 level1 lfo3">Clearly communicate with project team members and other Pfizer colleagues.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l2 level1 lfo3">Consistently record your experimental results in an electronic laboratory notebook and comply with all Pfizer safety policies.<o:p></o:p></li></ul>
<p class="MsoNormal"><b><u><o:p><span style="text-decoration:none"> </span></o:p></u></b></p>
<p class="MsoNormal"><b><u>BASIC QUALIFICATIONS <o:p></o:p></u></b></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="margin-left:-.25in;mso-list:l4 level1 lfo6">Doctoral degree or equivalent in Biochemistry, Biophysics, Physics, Chemistry or related field.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l4 level1 lfo6">Postdoctoral training in cryo-EM with 1-3 years of industrial or academic experience.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l4 level1 lfo6">Proven ability to independently design and conduct state-of-the-art single particle cryo-EM experiments, leading to a strong track record of successful outcomes with publications in top
tier journals.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l4 level1 lfo6">Must be able to thrive and deliver results in a fast paced, dynamic and highly multi-tasking environment.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l4 level1 lfo6">Broad knowledge in protein characterization, structural biology, biophysics and computational chemistry.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l4 level1 lfo6">Demonstrated ability to work independently and in teams in an inclusive manner<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l4 level1 lfo6">Proven scientific influence via strong interpersonal and communication skills; passionate about using structural data to influence key scientific decisions. Has the skill and drive to
grow into a thought leader.<o:p></o:p></li></ul>
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<p class="MsoNormal"><b><u>PREFERRED QUALIFICATIONS <o:p></o:p></u></b></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="margin-left:-.25in;mso-list:l0 level1 lfo9">Broad experience or familiarity with different aspects of structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art
software, and 3-D reconstruction.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l0 level1 lfo9">Passionate about the hardware and computing skills associated with EM such as microscope, direct electron detector, sample robot, computer cluster, etc. and their maintenance.<o:p></o:p></li><li class="MsoNormal" style="margin-left:-.25in;mso-list:l0 level1 lfo9">Ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams.<o:p></o:p></li></ul>
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