[3dem] postdoc opportunity at Imperial College London

Bubeck, Doryen A d.bubeck at imperial.ac.uk
Wed Jan 20 07:55:44 PST 2016


Applications are invited for a Postdoctoral Research Associate to join the laboratory of Dr. Doryen Bubeck.   The post, funded by Cancer Research UK, provides an exciting opportunity to work as a key member of an interdisciplinary structural biology project involving high resolution electron cryo-microscopy that has the potential to impact actively prescribed cancer therapeutics.

The project involves structural and functional characterization of protein complexes involved in the complement terminal pathway.

Complement plays an important role in monoclonal antibody (mAb)-based cancer immunotherapy through complement-dependent cytotoxicity (CDC). One mechanism of tumor clearance is by the deposition of membrane attack complex (MAC) pores on target cells. The effectiveness of CDC remains limited in some cancers due to over expression of CD59, a membrane-bound complement regulator that inhibits MAC-mediated lysis. Broadly the goal of this project is to understand how MAC pores are assembled and regulated in lipid bilayers.

The Centre for Structural Biology is a state-of-the-art electron microscopy facility equipped with two FEG electron microscopes and cutting edge dectectors (4k x 4k CCD and FEI Falcon II direct electron detector). The project will involve regular access to Titan Krios facilities at eBIC (Diamond Light Source, UK) and IGBMC-CERBM (Strasbourg, France).


Please find the attached full job description and advertisement.

Best wishes,

Doryen
------------------------------------
Doryen Bubeck
506 Sir Ernst Chain Building
Imperial College
London SW7 2AZ

d.bubeck at imperial.ac.uk
+44 (0)2075942989
--------------------------------------
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20160120/bd1877e4/attachment-0001.html>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: NS2016018LP_DB.pdf
Type: application/pdf
Size: 72746 bytes
Desc: NS2016018LP_DB.pdf
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20160120/bd1877e4/attachment-0002.pdf>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: NS2016018LP_JD_DB.pdf
Type: application/pdf
Size: 97427 bytes
Desc: NS2016018LP_JD_DB.pdf
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20160120/bd1877e4/attachment-0003.pdf>


More information about the 3dem mailing list