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<p class="MsoNormal" style="text-align:justify">Applications are invited for a Postdoctoral Research Associate to join the laboratory of Dr. Doryen Bubeck. The post, funded by Cancer Research UK, provides an exciting opportunity to work as a key member of
an interdisciplinary structural biology project involving high resolution electron cryo-microscopy that has the potential to impact actively prescribed cancer therapeutics.
<o:p></o:p></p>
<p class="MsoNormal" style="text-align:justify"><o:p> </o:p></p>
<p class="MsoNormal" style="text-align:justify">The project involves structural and functional characterization of protein complexes involved in the complement terminal pathway. <o:p></o:p></p>
<p class="MsoNormal" style="text-align:justify"><o:p> </o:p></p>
<p class="MsoNormal" style="text-align:justify">Complement plays an important role in monoclonal antibody (mAb)-based cancer immunotherapy through complement-dependent cytotoxicity (CDC). One mechanism of tumor clearance is by the deposition of membrane attack
complex (MAC) pores on target cells. The effectiveness of CDC remains limited in some cancers due to over expression of CD59, a membrane-bound complement regulator that inhibits MAC-mediated lysis. Broadly the goal of this project is to understand how MAC
pores are assembled and regulated in lipid bilayers. <o:p></o:p></p>
<p class="MsoNormal" style="text-align:justify"><o:p> </o:p></p>
<span style="font-size:11.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";
mso-bidi-font-family:ArialMT;mso-ansi-language:EN-GB;mso-fareast-language:EN-US;
mso-bidi-language:AR-SA">The Centre for Structural Biology is a state-of-the-art electron
microscopy facility equipped with two FEG electron microscopes and cutting edge dectectors (4k x 4k CCD and FEI Falcon II direct electron detector). The project will involve regular access to Titan Krios facilities at eBIC (Diamond Light Source, UK) and IGBMC-CERBM
(Strasbourg, France).</span></div>
<div style="color: rgb(0, 0, 0); font-family: Calibri, sans-serif; font-size: 14px;">
<span style="font-size:11.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";
mso-bidi-font-family:ArialMT;mso-ansi-language:EN-GB;mso-fareast-language:EN-US;
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<div style="color: rgb(0, 0, 0); font-family: Calibri, sans-serif; font-size: 14px;">
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</span></div>
<div><font face="Arial" size="3">Please find the attached full job description and </font><font face="Arial"><span style="font-size: 15px;">advertisement</span></font><font face="Arial" size="3">.</font></div>
<div><font face="Arial" size="3"><br>
</font></div>
<div><font face="Arial" size="3">Best wishes,</font></div>
<div><font face="Arial" size="3"><br>
</font></div>
<div><font face="Arial" size="3">Doryen </font><!--EndFragment--></div>
<div style="color: rgb(0, 0, 0); font-family: Calibri, sans-serif; font-size: 14px;">
<div>------------------------------------</div>
<div>Doryen Bubeck</div>
<div>506 Sir Ernst Chain Building</div>
<div>Imperial College</div>
<div>London SW7 2AZ</div>
<div><br>
</div>
<div>d.bubeck@imperial.ac.uk</div>
<div>+44 (0)2075942989</div>
<div>--------------------------------------</div>
</div>
</div>
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