[3dem] Opportunities at UVa

[Edward Egelman]

*Opportunities in Cryo-EM of Protein and Nucleoprotein Polymers at the 
University of Virginia.*
The Egelman lab has developed the main method (IHRSR) that is now being 
used around the world for reconstructing helical polymers at high 
resolution. Current projects in the Egelman lab include the application 
and further development of these methods to helical viruses (DiMaio et 
al., 2015a; DiMaio et al., 2015b), bacterial secretion systems 
(Kudryashev et al., 2015), designed polymers (Egelman et al., 2015), and 
proteins involved in inflammation and innate immunity (Lu et al., 2014). 
A full publication list can be found at 
http://people.virginia.edu/~ehe2n. The facilities are exceptional, and 
include a Titan Krios equipped with a Falcon II direct electron 
detector. If interested please contact Edward Egelman at 
egelman at virginia.edu.

DiMaio, F., Chen, C.C., Yu, X., Frenz, B., Hsu, Y.H., Lin, N.S., and 
Egelman, E.H. (2015a). The molecular basis for flexibility in the 
flexible filamentous plant viruses. Nat Struct Mol Biol 22, 642-644.

DiMaio, F., Yu, X., Rensen, E., Krupovic, M., Prangishvili, D., and 
Egelman, E.H. (2015b). A Virus that Infects a Hyperthermophile 
Encapsidates A-Form DNA. Science 348, 914-917.

Egelman, E.H., Xu, C., DiMaio, F., Magnotti, E., Modlin, C., Yu, X., 
Wright, E., Baker, D., and Conticello, V.P. (2015). Structural 
plasticity of helical nanotubes based on coiled-coil assemblies. 
Structure 23, 280-289.

Kudryashev, M., Wang, R.Y., Brackmann, M., Scherer, S., Maier, T., 
Baker, D., DiMaio, F., Stahlberg, H., Egelman, E.H., and Basler, M. 
(2015). Structure of the Type VI Secretion System Contractile Sheath. 
Cell 160, 952-962.

Lu, A., Magupalli, V.G., Ruan, J., Yin, Q., Atianand, M.K., Vos, M.R., 
Schroder, G.F., Fitzgerald, K.A., Wu, H., and Egelman, E.H. (2014). 
Unified Polymerization Mechanism for the Assembly of ASC-Dependent 
Inflammasomes. Cell 156, 1193-1206.

-- 


Edward H. Egelman, Ph.D.

Professor

Dept. of Biochemistry and Molecular Genetics

University of Virginia

President

Biophysical Society

phone: 434-924-8210

fax: 434-924-5069

egelman at virginia.edu

http://www.people.virginia.edu/~ehe2n 
<http://www.people.virginia.edu/%7Eehe2n>


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