[3dem] 10 days left to apply: Cryo-Electron Microscopy Postdoctoral Position

[Speck, Christian]

Dear All,

An exciting opportunity has arisen  to join the laboratory of Dr Christian Speck in the Institute of Clinical Sciences, Faculty of Medicine at the Hammersmith Campus of Imperial College London (http://www.specklab.com/). The Postdoctoral position is full-time for 3 years with the possibility for extension and the salary range is £33,860 - £42,830 per annum.The successful applicant will become part of a group of multi-disciplinary colleagues and collaborators and will investigate fundamental biological mechanisms in eukaryotic DNA replication using cryo-EM approaches.

A vital property of all living things is the ability to replicate their DNA, allowing cells to pass on their genetic material from parent to progeny. The successful candidate will employ cryo-EM to address two of the most fundamental questions in eukaryotic DNA replication: how the replicative helicase becomes loaded onto DNA and activated for DNA synthesis. This knowledge will be crucial to understand how misregulation of DNA replication leads to disease and for the development of novel DNA replication inhibitors with potential as anti-cancer drugs.

The work will be performed in collaboration with Prof. Xiaodong Zhang (Imperial College London), Prof. Richard Henderson (MRC, Laboratory of Molecular Biology) and our long-term collaborator Prof. Huilin Li (Brookhaven National Laboratory), who will also help to mentor and advise a postdoctoral fellow. The candidate will have full access to the well-equipped cryo-EM facility at Imperial College London. Regular access to a Titan Krios will be possible. By joining the group the candidate will not only participate in high profile research projects, but will be also mentored in successful grant writing, networking and publishing. Crucially, the candidate will also have direct access to protein samples (Fernandez-Cid et al Mol Cell 2013<http://www.ncbi.nlm.nih.gov/pubmed/23603117>, Herrera et al NAR 2015<http://www.ncbi.nlm.nih.gov/pubmed/26338774>) produced by group members, which are ideally suited for high resolution cryo-EM.

The candidates will be expected to hold a PhD in Structural Biology/Biochemistry or have equivalent experience. They must have extensive expertise in structural electron microscopy and good knowledge in protein purification. The latest start date is summer 2016.

For informal inquiries or questions please contact Christian Speck directly (chris.speck at imperial.ac.uk<mailto:chris.speck at imperial.ac.uk>).

Apply online via our website at http://www3.imperial.ac.uk/employment (select "Job Search" then enter the job title or vacancy reference number into "Keywords"). Please complete and upload an application form as directed quoting the appropriate reference number (HM2015169).

Alternatively, if you are unable to apply online, please email Katie.Hall at imperial.ac.uk<mailto:hmrecr at imperial.ac.uk> to request an application form.


Closing Date: 1 November 2015 (Midnight BST)

Best wishes,

Christian
__________________________________________

Christian Speck, PhD, FRSB
Reader in Genome Biochemistry & Molecular Biology
Wellcome Trust Investigator

* OPEN POSITIONS *<http://www.specklab.com/jobs.html#PostdoctoralFellowships>

Imperial College London
Faculty of Medicine
Institute of Clinical Sciences (CRB room 3006)
Hammersmith Hospital Campus
Du Cane Road
London W12 0NN

Tel: 0044 20 8383 3387
Mobile: 0044 796 181 5557

email: christian.speck at imperial.ac.uk<mailto:christian.speck at imperial.ac.uk>
website: www.specklab.com<http://www.specklab.com/>
Imperial College website: www.imperial.ac.uk/people/chris.speck<http://www.imperial.ac.uk/people/chris.speck>

[http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtvm050463.jpg][Athena Swan Bronze Award Logo]<http://www.athenaswan.org.uk/>

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