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<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">Dear All,<b><o:p></o:p></b></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">An exciting opportunity has arisen to join the laboratory of Dr Christian Speck in the Institute of Clinical Sciences, Faculty of Medicine at the Hammersmith Campus
of Imperial College London (<a href="http://www.specklab.com">http://www.specklab.com</a>/). The Postdoctoral position is full-time for 3 years with the possibility for extension and the salary range is £33,860 - £42,830 per annum.The successful applicant
will become part of a group of multi-disciplinary colleagues and collaborators and will investigate fundamental biological mechanisms in eukaryotic DNA replication using cryo-EM approaches.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">A vital property of all living things is the ability to replicate their DNA, allowing cells to pass on their genetic material from parent to progeny. The successful
candidate will employ cryo-EM to address two of the most fundamental questions in eukaryotic DNA replication: how the replicative helicase becomes loaded onto DNA and activated for DNA synthesis. This knowledge will be crucial to understand how misregulation
of DNA replication leads to disease and for the development of novel DNA replication inhibitors with potential as anti-cancer drugs.
<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">The work will be performed in collaboration with Prof. Xiaodong Zhang (Imperial College London), Prof. Richard Henderson (MRC, Laboratory of Molecular Biology) and
our long-term collaborator Prof. Huilin Li (Brookhaven National Laboratory), who will also help to mentor and advise a postdoctoral fellow. The candidate will have full access to the well-equipped cryo-EM facility at Imperial College London. Regular access
to a Titan Krios will be possible. By joining the group the candidate will not only participate in high profile research projects, but will be also mentored in successful grant writing, networking and publishing. Crucially, the candidate will also have direct
access to protein samples (</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/23603117"><span style="font-family:"Arial",sans-serif">Fernandez-Cid et al Mol Cell 2013</span></a><span style="font-family:"Arial",sans-serif">,
</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/26338774"><span style="font-family:"Arial",sans-serif">Herrera et al NAR 2015</span></a><span style="font-family:"Arial",sans-serif">) produced by group members, which are ideally suited for high resolution
cryo-EM.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">The candidates will
</span><span lang="EN" style="font-family:"Arial",sans-serif">be expected to hold a PhD
</span><span style="font-family:"Arial",sans-serif">in Structural Biology<span style="color:#1F497D">/</span>Biochemistry or have equivalent experience. They must have extensive expertise in structural electron microscopy and good knowledge in protein purification.
The latest start date is summer 2016. <o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">For informal inquiries or questions please contact Christian Speck directly (</span><a href="mailto:chris.speck@imperial.ac.uk"><span style="font-family:"Arial",sans-serif">chris.speck@imperial.ac.uk</span></a><span style="font-family:"Arial",sans-serif">).<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">Apply online via our website at
</span><a href="http://www3.imperial.ac.uk/employment"><span style="font-family:"Arial",sans-serif">http://www3.imperial.ac.uk/employment</span></a><span style="font-family:"Arial",sans-serif"> (select “Job Search” then enter the job title or vacancy reference
number into “Keywords”). Please complete and upload an application form as directed
<b>quoting the appropriate reference number (HM2015169).<o:p></o:p></b></span></p>
<p class="MsoNormal" style="text-align:justify"><b><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">Alternatively, if you are unable to apply online, please email
</span><a href="mailto:hmrecr@imperial.ac.uk"><span style="font-family:"Arial",sans-serif">Katie.Hall@imperial.ac.uk</span></a><span style="font-family:"Arial",sans-serif"> to request an application form.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoBodyText"><b><span lang="EN-US" style="font-size:11.0pt">Closing Date: 1 November 2015 (Midnight BST)<o:p></o:p></span></b></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal">Best wishes,<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Christian<o:p></o:p></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">__________________________________________</span></i><i><span style="font-size:12.0pt;mso-fareast-language:EN-GB"><o:p></o:p></span></i></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">Christian Speck, PhD, FRSB<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">Reader in Genome Biochemistry & Molecular Biology</span></i><span style="mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">Wellcome Trust Investigator</span></i><span style="mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB"><o:p> </o:p></span></i></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB"><a href="http://www.specklab.com/jobs.html#PostdoctoralFellowships"><span style="color:blue">* OPEN POSITIONS *</span></a><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB"><o:p> </o:p></span></i></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">Imperial College London<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">Faculty of Medicine<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">Institute of Clinical Sciences (CRB room 3006)<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">Hammersmith Hospital Campus<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">Du Cane Road<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">London W12 0NN<o:p></o:p></span></i></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">Tel: 0044 20 8383 3387
<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">Mobile: 0044 796 181 5557<o:p></o:p></span></i></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:EN-GB">email: <span style="color:blue">
<a href="mailto:christian.speck@imperial.ac.uk"><span style="color:blue;font-style:normal">christian.speck@imperial.ac.uk</span></a></span></span></i><span style="mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-size:10.0pt;font-family:"Arial",sans-serif;mso-fareast-language:EN-GB">website:
</span></i><span style="font-size:10.0pt;font-family:"Arial",sans-serif;mso-fareast-language:EN-GB"><a href="http://www.specklab.com/"><i><span style="color:blue">www.specklab.com</span></i></a><i>
<span style="color:red"><o:p></o:p></span></i></span></p>
<p class="MsoNormal"><i><span style="font-size:10.0pt;font-family:"Arial",sans-serif;mso-fareast-language:EN-GB">Imperial College website:</span></i><span style="mso-fareast-language:EN-GB">
<i><a href="http://www.imperial.ac.uk/people/chris.speck"><span style="color:blue">www.imperial.ac.uk/people/chris.speck</span></a></i><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB"><img border="0" width="354" height="111" id="Picture_x0020_1" src="cid:image001.jpg@01D10CE0.FD683E50" alt="http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtvm050463.jpg"></span><a href="http://www.athenaswan.org.uk/" target="_blank"><span style="color:blue;mso-fareast-language:EN-GB;text-decoration:none"><img border="0" width="168" height="92" id="Picture_x0020_2" src="cid:image002.png@01D10CE0.FD683E50" alt="Athena Swan Bronze Award Logo"></span></a><span style="mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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