[3dem] PhD opportunity at University of Freiburg

[Eva Rog]

Hello all! We have an opening for a PhD student to work on cardiomyocyte-neuron nano-dynamics using 'time-resolved' EM and correlative methods in hiPSC models. If you know anyone who might be interested 🙂Link and short description of the project is below!

https://urldefense.com/v3/__https://uni-freiburg.de/for6051/wp-content/uploads/sites/529/FOR6051_advert-project-description_P2-2.pdf__;!!Mih3wA!G7bPnRFmesqbUiK9ESFMM0DseydvNcnfTqA_s3zlsf3gaqbhPgHog7K9qzg_WTvkoS5fQogaVXhFw8mB5aJT$ 

Background: The intracardiac nervous system plays a fundamental role in the fine-tuned regulation of cardiac function. The efficiency and precision of neuro–cardiac communication are thought to be critically determined by the ultrastructural geometry of the interface between neurons and cardiomyocytes. This specialised microdomain – referred to as the neuro–cardiac junction – is believed to spatially and temporarily integrate pre-synaptic, synaptic, and post-synaptic events. Despite its functional importance, the nano-scale architecture and dynamic organisation of the neuro–cardiac junction remain poorly understood.

Project Description: The project will explore the structural organisation and functional properties of the neuro–cardiac junction at the nano-scale. This will be achieved using human induced pluripotent stem cell (hiPSC)-based in vitro neuron– cardiomyocyte co-cultures, combined with advanced high resolution light and electron microscopy, and live-cell functional studies. These studies will be complemented by analyses of intact cardiac tissue, and be closely integrated with organ-level investigation carried out by a PhD student at the partner team at the Institute.

Best wishes, Eva Rog-Zielinska

Section Leader
Cardiac NanoDynamics/4D Imaging

Institute for Experimental Cardiovascular Medicine
UNIVERSITÄTSKLINIKUM FREIBURG
Universitäts-Herzzentrum

Elsaesser Str. 4C · 79110 Freiburg
Telefon +49 761 270 63954

eva.rog-zielinska at uniklinik-freiburg.de

https://urldefense.com/v3/__https://www.herzzentrum.de/englisch/departments-sections/institute-for-experimental-cardiovascular-medicine/research/4d-imaging-cardiac-nanodynamics.html__;!!Mih3wA!G7bPnRFmesqbUiK9ESFMM0DseydvNcnfTqA_s3zlsf3gaqbhPgHog7K9qzg_WTvkoS5fQogaVXhFwxCLPoby$ 

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