[3dem] Postdoctoral Position in Strasbourg, France: Cryo-Electron Tomography and Biological Physics

[Florian FAESSLER]

Dear all,

The Fäßler and Riveline teams at IGBMC are seeking a highly motivated Postdoctoral researcher to investigate the mechanisms underlying cytokinetic actomyosin ring closure. This interdisciplinary project combines in situ ultrastructural analyses—revealing actin filament polarity and myosin distribution—with live-cell imaging. Our objective is to develop a comprehensive understanding of this fundamental step in cell division.

IGBMC hosts strong international communities of cell and structural biologists and houses excellent light- and electron microscopy equipment, including a Titan Krios G4. It is located on the outskirts of Strasbourg, a student city in the center of Europe, and near the Vosges and Schwarzwald mountain ranges, offering excellent opportunities to unwind and refocus.

If you are interested in joining us, please send your application by the 11th of May as a single PDF file containing your CV, a motivation letter (max. 1 page), and a paragraph on how the application of cryo-electron tomography (could have) advanced your PhD work or this topic (max. 1 page), and the contact details of at least 2 references to florian.faessler at igbmc.fr and riveline at igbmc.fr. Please send further questions regarding the position also to these addresses.

As cryo-electron tomography, from specimen preparation to (ultra-) structural analysis, is at the heart of the project, prior experience in the relevant techniques, especially in high-pressure freezing and focused ion-beam milling, is considered an advantage during the selection process for the position. We also encourage applications from potential candidates with expertise in other (cryo-) electron microscopic approaches, live cell imaging, or biological physics who are keen to become versed in cryo-electron tomography.


Please find below references to our works covering adjacent topics:

    Wollrab, V., Thiagarajan, R., Wald, A., Kruse, K., & Riveline, D. (2016). Still and rotating myosin clusters determine cytokinetic ring constriction.
    Nature Communications, 7(1), 11860. https://urldefense.com/v3/__https://doi.org/10.1038/ncomms11860__;!!Mih3wA!GtFuMBFHVIBSTLFHOl_douW9_rDbRBLJrzcGLPDXV-N6PBdS_o9KgK83E8NgVwyxjFbSsLT82sCHT9xycxBrPA$ 

    Fäßler, F., Dimchev, G., Hodirnau, V.-V., Wan, W., & Schur, F. K. M. (2020). Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction.
    Nature Communications, 11(1), Article 1. https://urldefense.com/v3/__https://doi.org/10.1038/s41467-020-20286-x__;!!Mih3wA!GtFuMBFHVIBSTLFHOl_douW9_rDbRBLJrzcGLPDXV-N6PBdS_o9KgK83E8NgVwyxjFbSsLT82sCHT9zFcp33DA$ 

    Fäßler, F., Javoor, M. G., Datler, J., Döring, H., Hofer, F. W., Dimchev, G., Hodirnau, V.-V., Faix, J., Rottner, K., & Schur, F. K. M. (2023). ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning.
    Science Advances, 9(3), eadd6495. https://urldefense.com/v3/__https://doi.org/10.1126/sciadv.add6495__;!!Mih3wA!GtFuMBFHVIBSTLFHOl_douW9_rDbRBLJrzcGLPDXV-N6PBdS_o9KgK83E8NgVwyxjFbSsLT82sCHT9yL1vraYA$ 

    Lu, L., Guyomar, T., Vagne, Q., Berthoz, R., Torres-Sánchez, A., Lieb, M., Martin-Lemaitre, C., van Unen, K., Honigmann, A., Pertz, O., Riveline, D., & Salbreux, G. (2024). Polarity-driven three-dimensional spontaneous rotation of a cell doublet.
    Nature Physics, 20(7), 1194–1203. https://urldefense.com/v3/__https://doi.org/10.1038/s41567-024-02460-w__;!!Mih3wA!GtFuMBFHVIBSTLFHOl_douW9_rDbRBLJrzcGLPDXV-N6PBdS_o9KgK83E8NgVwyxjFbSsLT82sCHT9w7dJA8HA$ 

    Lo Vecchio, S., Pertz, O., Szopos, M., Navoret, L., & Riveline, D. (2024). Spontaneous rotations in epithelia as an interplay between cell polarity and boundaries.
    Nature Physics, 20(2), 322–331. https://urldefense.com/v3/__https://doi.org/10.1038/s41567-023-02295-x__;!!Mih3wA!GtFuMBFHVIBSTLFHOl_douW9_rDbRBLJrzcGLPDXV-N6PBdS_o9KgK83E8NgVwyxjFbSsLT82sCHT9xiW5Rojg$ 
<https://urldefense.com/v3/__https://www.nature.com/articles/s41567-023-02295-x__;!!Mih3wA!GtFuMBFHVIBSTLFHOl_douW9_rDbRBLJrzcGLPDXV-N6PBdS_o9KgK83E8NgVwyxjFbSsLT82sCHT9xwkl1Row$ >


Best,

Florian

________________________________________________

Florian Fäßler

Inserm Junior Professor Chair

Department of Integrated Structural Biology

Institute of Genetics and of Molecular and Cellular Biology (IGBMC)

1, rue Laurent Fries

BP 10142

67404 Illkirch Cedex

France


Email: florian.faessler at igbmc.fr

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