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<div>Dear all,</div>
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<div>The Fäßler and Riveline teams at IGBMC are seeking a highly motivated Postdoctoral researcher to investigate the mechanisms underlying cytokinetic actomyosin ring closure. This interdisciplinary project combines in situ ultrastructural analyses—revealing
actin filament polarity and myosin distribution—with live-cell imaging. Our objective is to develop a comprehensive understanding of this fundamental step in cell division.
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IGBMC hosts strong international communities of cell and structural biologists and houses excellent light- and electron microscopy equipment, including a Titan Krios G4. It is located on the outskirts of Strasbourg, a student city in the center of Europe, and
near the Vosges and Schwarzwald mountain ranges, offering excellent opportunities to unwind and refocus.
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If you are interested in joining us, please send your application by the 11th of May as a single PDF file containing your CV, a motivation letter (max. 1 page), and a paragraph on how the application of cryo-electron tomography (could have) advanced your PhD
work or this topic (max. 1 page), and the contact details of at least 2 references to florian.faessler@igbmc.fr and riveline@igbmc.fr. Please send further questions regarding the position also to these addresses.
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As cryo-electron tomography, from specimen preparation to (ultra-) structural analysis, is at the heart of the project, prior experience in the relevant techniques, especially in high-pressure freezing and focused ion-beam milling, is considered an advantage
during the selection process for the position. We also encourage applications from potential candidates with expertise in other (cryo-) electron microscopic approaches, live cell imaging, or biological physics who are keen to become versed in cryo-electron
tomography. <br>
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Please find below references to our works covering adjacent topics: <br>
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<span style="font-size: 11pt;"> Wollrab, V., Thiagarajan, R., Wald, A., Kruse, K., &
</span><b><span style="font-size: 11pt;">Riveline, D.</span></b><span style="font-size: 11pt;"> (2016). Still and rotating myosin clusters determine cytokinetic ring constriction.
</span><br>
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<div><span style="font-size: 11pt;"> Nature Communications, 7(1), 11860. <a href="https://urldefense.com/v3/__https://doi.org/10.1038/ncomms11860__;!!Mih3wA!GtFuMBFHVIBSTLFHOl_douW9_rDbRBLJrzcGLPDXV-N6PBdS_o9KgK83E8NgVwyxjFbSsLT82sCHT9xycxBrPA$" class="OWAAutoLink" id="LPlnk787106">
https://doi.org/10.1038/ncomms11860</a> </span><br>
<span style="font-size: 11pt;"></span><br>
<span style="font-size: 11pt;"> </span><b><span style="font-size: 11pt;">Fäßler, F.</span></b><span style="font-size: 11pt;">, Dimchev, G., Hodirnau, V.-V., Wan, W., & Schur, F. K. M. (2020). Cryo-electron tomography structure of Arp2/3 complex in cells
reveals new insights into the branch junction. </span><br>
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<div><span style="font-size: 11pt;"> Nature Communications, 11(1), Article 1. <a href="https://urldefense.com/v3/__https://doi.org/10.1038/s41467-020-20286-x__;!!Mih3wA!GtFuMBFHVIBSTLFHOl_douW9_rDbRBLJrzcGLPDXV-N6PBdS_o9KgK83E8NgVwyxjFbSsLT82sCHT9zFcp33DA$" class="OWAAutoLink">
https://doi.org/10.1038/s41467-020-20286-x</a> </span><br>
<span style="font-size: 11pt;"></span><br>
<span style="font-size: 11pt;"> </span><b><span style="font-size: 11pt;">Fäßler, F.</span></b><span style="font-size: 11pt;">, Javoor, M. G., Datler, J., Döring, H., Hofer, F. W., Dimchev, G., Hodirnau, V.-V., Faix, J., Rottner, K., & Schur, F. K. M. (2023).
ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning.
</span><br>
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<div><span style="font-size: 11pt;"> </span><span style="font-size: 11pt;">Science Advances, 9(3), eadd6495.
<a href="https://urldefense.com/v3/__https://doi.org/10.1126/sciadv.add6495__;!!Mih3wA!GtFuMBFHVIBSTLFHOl_douW9_rDbRBLJrzcGLPDXV-N6PBdS_o9KgK83E8NgVwyxjFbSsLT82sCHT9yL1vraYA$" class="OWAAutoLink">https://doi.org/10.1126/sciadv.add6495</a>
</span><br>
<span style="font-size: 11pt;"></span><br>
<span style="font-size: 11pt;"> Lu, L., Guyomar, T., Vagne, Q., Berthoz, R., Torres-Sánchez, A., Lieb, M., Martin-Lemaitre, C., van Unen, K., Honigmann, A., Pertz, O.,
</span><b><span style="font-size: 11pt;">Riveline, D.</span></b><span style="font-size: 11pt;">, & Salbreux, G. (2024). Polarity-driven three-dimensional spontaneous rotation of a cell doublet.
</span><br>
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<div><span style="font-size: 11pt;"> </span><span style="font-size: 11pt;">Nature Physics, 20(7), 1194–1203.
<a href="https://urldefense.com/v3/__https://doi.org/10.1038/s41567-024-02460-w__;!!Mih3wA!GtFuMBFHVIBSTLFHOl_douW9_rDbRBLJrzcGLPDXV-N6PBdS_o9KgK83E8NgVwyxjFbSsLT82sCHT9w7dJA8HA$" class="OWAAutoLink">https://doi.org/10.1038/s41567-024-02460-w</a>
</span><br>
<span style="font-size: 11pt;"></span><br>
<span style="font-size: 11pt;"> Lo Vecchio, S., Pertz, O., Szopos, M., Navoret, L., &
</span><b><span style="font-size: 11pt;">Riveline, D.</span></b><span style="font-size: 11pt;"> (2024). Spontaneous rotations in epithelia as an interplay between cell polarity and boundaries.
</span><br>
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<div><span style="font-size: 11pt;"> </span><span style="font-size: 11pt;">Nature Physics, 20(2), 322–331. <a href="https://urldefense.com/v3/__https://doi.org/10.1038/s41567-023-02295-x__;!!Mih3wA!GtFuMBFHVIBSTLFHOl_douW9_rDbRBLJrzcGLPDXV-N6PBdS_o9KgK83E8NgVwyxjFbSsLT82sCHT9xiW5Rojg$" class="OWAAutoLink">https://doi.org/10.1038/s41567-023-02295-x</a>
</span><br>
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<a href="https://urldefense.com/v3/__https://www.nature.com/articles/s41567-023-02295-x__;!!Mih3wA!GtFuMBFHVIBSTLFHOl_douW9_rDbRBLJrzcGLPDXV-N6PBdS_o9KgK83E8NgVwyxjFbSsLT82sCHT9xwkl1Row$" class="OWAAutoLink"></a><br>
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<p>Best,</p>
<p>Florian <br>
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<p>________________________________________________<br>
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<p>Florian Fäßler</p>
<p>Inserm Junior Professor Chair<br>
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<p>Department of Integrated Structural Biology</p>
<p><span>Institute of Genetics and of Molecular and Cellular Biology</span> (IGBMC)</p>
<p>1, rue Laurent Fries</p>
<p>BP 10142</p>
<p>67404 Illkirch Cedex</p>
<p>France<br>
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<p>Email: florian.faessler@igbmc.fr</p>
<p><span>________________________________________________</span><br>
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