[3dem] Opportunities at UVa
Edward Egelman
egelman at virginia.edu
Fri Sep 11 11:08:25 PDT 2015
*Opportunities in Cryo-EM of Protein and Nucleoprotein Polymers at the
University of Virginia.*
The Egelman lab has developed the main method (IHRSR) that is now being
used around the world for reconstructing helical polymers at high
resolution. Current projects in the Egelman lab include the application
and further development of these methods to helical viruses (DiMaio et
al., 2015a; DiMaio et al., 2015b), bacterial secretion systems
(Kudryashev et al., 2015), designed polymers (Egelman et al., 2015), and
proteins involved in inflammation and innate immunity (Lu et al., 2014).
A full publication list can be found at
http://people.virginia.edu/~ehe2n. The facilities are exceptional, and
include a Titan Krios equipped with a Falcon II direct electron
detector. If interested please contact Edward Egelman at
egelman at virginia.edu.
DiMaio, F., Chen, C.C., Yu, X., Frenz, B., Hsu, Y.H., Lin, N.S., and
Egelman, E.H. (2015a). The molecular basis for flexibility in the
flexible filamentous plant viruses. Nat Struct Mol Biol 22, 642-644.
DiMaio, F., Yu, X., Rensen, E., Krupovic, M., Prangishvili, D., and
Egelman, E.H. (2015b). A Virus that Infects a Hyperthermophile
Encapsidates A-Form DNA. Science 348, 914-917.
Egelman, E.H., Xu, C., DiMaio, F., Magnotti, E., Modlin, C., Yu, X.,
Wright, E., Baker, D., and Conticello, V.P. (2015). Structural
plasticity of helical nanotubes based on coiled-coil assemblies.
Structure 23, 280-289.
Kudryashev, M., Wang, R.Y., Brackmann, M., Scherer, S., Maier, T.,
Baker, D., DiMaio, F., Stahlberg, H., Egelman, E.H., and Basler, M.
(2015). Structure of the Type VI Secretion System Contractile Sheath.
Cell 160, 952-962.
Lu, A., Magupalli, V.G., Ruan, J., Yin, Q., Atianand, M.K., Vos, M.R.,
Schroder, G.F., Fitzgerald, K.A., Wu, H., and Egelman, E.H. (2014).
Unified Polymerization Mechanism for the Assembly of ASC-Dependent
Inflammasomes. Cell 156, 1193-1206.
--
Edward H. Egelman, Ph.D.
Professor
Dept. of Biochemistry and Molecular Genetics
University of Virginia
President
Biophysical Society
phone: 434-924-8210
fax: 434-924-5069
egelman at virginia.edu
http://www.people.virginia.edu/~ehe2n
<http://www.people.virginia.edu/%7Eehe2n>
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20150911/4d595365/attachment-0001.html>
More information about the 3dem
mailing list