[3dem] Opportunities at UVa
Edward Egelman
egelman at virginia.edu
Sat Sep 12 08:26:50 PDT 2015
*Opportunities in Cryo-EM of Protein and Nucleoprotein Polymers at the
University of Virginia.***The Egelman lab has developed the main method
(IHRSR) that is now being used around the world for reconstructing
helical polymers at high resolution. Current projects in the Egelman lab
include the application and further development of these methods to
helical viruses (1,2), bacterial secretion systems (3), designed
polymers (4), and proteins involved in inflammation and innate immunity
(5). A full publication list can be found at people.virginia.edu/~ehe2n.
The facilities are exceptional, and include a Titan Krios equipped with
a Falcon II direct electron detector. If interested please contact Ed
Egelman at egelman at virginia.edu.
1 DiMaio, F. et al. A Virus that Infects a Hyperthermophile
Encapsidates A-Form DNA. Science 348, 914-917 (2015).
2 DiMaio, F. et al. The molecular basis for flexibility in the
flexible filamentous plant viruses. Nat Struct Mol Biol 22, 642-644 (2015).
3 Kudryashev, M. et al. Structure of the Type VI Secretion
System Contractile Sheath. Cell 160, 952-962 (2015).
4 Egelman, E. H. et al. Structural plasticity of helical
nanotubes based on coiled-coil assemblies. Structure 23, 280-289 (2015).
5 Lu, A. et al. Unified Polymerization Mechanism for the
Assembly of ASC-Dependent Inflammasomes. Cell 156, 1193-1206 (2014).
More information about the 3dem
mailing list