[3dem] [EXTERNAL] Re: New game to learn/train cryo-EM/ET map resolution recognition

[Reza Khayat]

This is an important tool. How did you determine the resolution? Did you calculate it or is it experimental? Perhaps next version should include anisotropy for SPA and missing wedge for STA. Also, the 20 and 15Angstroms may be too close to distinguish for a beginner. In fact, being able to reach sub-nanometer was a blessing because it allowed us to move beyond the twilight zone.

Best wishes,
Reza
________________________________
From: 3dem <3dem-bounces at ncmir.ucsd.edu> on behalf of Ayil Perrott via 3dem <3dem at ncmir.ucsd.edu>
Sent: 21 April 2026 12:58 PM
To: Leandro F. Estrozi <leandro.estrozi at ibs.fr>
Cc: 3dem at ncmir.ucsd.edu <3dem at ncmir.ucsd.edu>; CCPEM at jiscmail.ac.uk <CCPEM at jiscmail.ac.uk>
Subject: [EXTERNAL] Re: [3dem] New game to learn/train cryo-EM/ET map resolution recognition

Leandro,

This game is amazing! I just played a few rounds on my lunch break and had so much fun! I think this is a wonderful tool to help students and beginners get more familiar with looking at structures, I even found myself learning a thing or two about it.

What are your plans for expanding this game, that is, beyond including noise in the maps? Do you have any plans for identifying point symmetry/asymmetry, structural heterogeneity, classification based on structural (dis)similarity, etc.? I think those would be really good additions as well, especially for helping train the eyes of newbies.

Wonderful job, and can't wait to see how you expand upon it!

Sincerely,
Ayil Perrott
(they/them)
--
Doctoral Student
Department of Cellular, Molecular, and Genetic Medicine
Virginia Commonwealth University
Richmond, VA

El mar, 21 abr 2026, 12:44, Leandro F. Estrozi via 3dem <3dem at ncmir.ucsd.edu<mailto:3dem at ncmir.ucsd.edu>> escribió:
Dear colleagues,

I am pleased to share a new online training game designed for newcomers
in structural biology, with a focus on cryo-EM and cryo-ET map
interpretation:

https://urldefense.com/v3/__https://rico.ibs.fr/helixplorer/resolution/__;!!Mih3wA!EJvDy_wVZYtD-rptRWtrUxbq7A8pGA1ZjbK_kAX9nYpXHYtdekjFvrioD4obUpLP_o_2rpttEOrdDSTtQBS4juXqBm9W$

A common challenge in the field is learning to recognize whether a 3D
map is consistent with a given resolution estimate. Confusing, for
example, a 4 Å map with an 8 Å map can lead to substantial time loss
during model building and interpretation. This game was created to help
users develop an intuition for the structural features visible across
the range of resolutions typically obtained in cryo-EM/ET.

It is aimed mainly at students and beginners, but others may also find
it fun or useful as a quick training exercise.

I should note that I am fully aware that noise plays an important role
in real cryo-EM/ET data, and this first version of the game does not yet
include noise.

Feedback is very welcome. Please feel free to share it with anyone who
might be interested.

Best regards,

Leandro.

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