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This is an important tool. How did you determine the resolution? Did you calculate it or is it experimental? Perhaps next version should include anisotropy for SPA and missing wedge for STA. Also, the 20 and 15Angstroms may be too close to distinguish for a
beginner. In fact, being able to reach sub-nanometer was a blessing because it allowed us to move beyond the twilight zone. </div>
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Best wishes,</div>
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Reza</div>
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<div id="divRplyFwdMsg" dir="ltr"><font face="Calibri, sans-serif" style="font-size:11pt" color="#000000"><b>From:</b> 3dem <3dem-bounces@ncmir.ucsd.edu> on behalf of Ayil Perrott via 3dem <3dem@ncmir.ucsd.edu><br>
<b>Sent:</b> 21 April 2026 12:58 PM<br>
<b>To:</b> Leandro F. Estrozi <leandro.estrozi@ibs.fr><br>
<b>Cc:</b> 3dem@ncmir.ucsd.edu <3dem@ncmir.ucsd.edu>; CCPEM@jiscmail.ac.uk <CCPEM@jiscmail.ac.uk><br>
<b>Subject:</b> [EXTERNAL] Re: [3dem] New game to learn/train cryo-EM/ET map resolution recognition</font>
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<div>Leandro,</div>
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<div dir="auto">This game is amazing! I just played a few rounds on my lunch break and had so much fun! I think this is a wonderful tool to help students and beginners get more familiar with looking at structures, I even found myself learning a thing or two
about it.</div>
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<div dir="auto">What are your plans for expanding this game, that is, beyond including noise in the maps? Do you have any plans for identifying point symmetry/asymmetry, structural heterogeneity, classification based on structural (dis)similarity, etc.? I think
those would be really good additions as well, especially for helping train the eyes of newbies.</div>
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<div dir="auto">Wonderful job, and can't wait to see how you expand upon it!</div>
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<div dir="ltr">Sincerely,
<div>Ayil Perrott</div>
<div>(they/them)</div>
<div>--</div>
<div>Doctoral Student</div>
<div>Department of Cellular, Molecular, and Genetic Medicine</div>
<div>Virginia Commonwealth University</div>
<div>Richmond, VA</div>
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<div dir="ltr" class="x_gmail_attr">El mar, 21 abr 2026, 12:44, Leandro F. Estrozi via 3dem <<a href="mailto:3dem@ncmir.ucsd.edu">3dem@ncmir.ucsd.edu</a>> escribió:<br>
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Dear colleagues,<br>
<br>
I am pleased to share a new online training game designed for newcomers <br>
in structural biology, with a focus on cryo-EM and cryo-ET map <br>
interpretation:<br>
<br>
<a href="https://urldefense.com/v3/__https://rico.ibs.fr/helixplorer/resolution/__;!!Mih3wA!EJvDy_wVZYtD-rptRWtrUxbq7A8pGA1ZjbK_kAX9nYpXHYtdekjFvrioD4obUpLP_o_2rpttEOrdDSTtQBS4juXqBm9W$" rel="noreferrer noreferrer" target="_blank">https://urldefense.com/v3/__https://rico.ibs.fr/helixplorer/resolution/__;!!Mih3wA!EJvDy_wVZYtD-rptRWtrUxbq7A8pGA1ZjbK_kAX9nYpXHYtdekjFvrioD4obUpLP_o_2rpttEOrdDSTtQBS4juXqBm9W$</a>
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<br>
A common challenge in the field is learning to recognize whether a 3D <br>
map is consistent with a given resolution estimate. Confusing, for <br>
example, a 4 Å map with an 8 Å map can lead to substantial time loss <br>
during model building and interpretation. This game was created to help <br>
users develop an intuition for the structural features visible across <br>
the range of resolutions typically obtained in cryo-EM/ET.<br>
<br>
It is aimed mainly at students and beginners, but others may also find <br>
it fun or useful as a quick training exercise.<br>
<br>
I should note that I am fully aware that noise plays an important role <br>
in real cryo-EM/ET data, and this first version of the game does not yet <br>
include noise.<br>
<br>
Feedback is very welcome. Please feel free to share it with anyone who <br>
might be interested.<br>
<br>
Best regards,<br>
<br>
Leandro.<br>
<br>
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