[3dem] New game to learn/train cryo-EM/ET map resolution recognition

[Ayil Perrott]

Leandro,

This game is amazing! I just played a few rounds on my lunch break and had
so much fun! I think this is a wonderful tool to help students and
beginners get more familiar with looking at structures, I even found myself
learning a thing or two about it.

What are your plans for expanding this game, that is, beyond including
noise in the maps? Do you have any plans for identifying point
symmetry/asymmetry, structural heterogeneity, classification based on
structural (dis)similarity, etc.? I think those would be really good
additions as well, especially for helping train the eyes of newbies.

Wonderful job, and can't wait to see how you expand upon it!

Sincerely,
Ayil Perrott
(they/them)
--
Doctoral Student
Department of Cellular, Molecular, and Genetic Medicine
Virginia Commonwealth University
Richmond, VA

El mar, 21 abr 2026, 12:44, Leandro F. Estrozi via 3dem <3dem at ncmir.ucsd.edu>
escribió:

> Dear colleagues,
>
> I am pleased to share a new online training game designed for newcomers
> in structural biology, with a focus on cryo-EM and cryo-ET map
> interpretation:
>
>
> https://urldefense.com/v3/__https://rico.ibs.fr/helixplorer/resolution/__;!!Mih3wA!EJvDy_wVZYtD-rptRWtrUxbq7A8pGA1ZjbK_kAX9nYpXHYtdekjFvrioD4obUpLP_o_2rpttEOrdDSTtQBS4juXqBm9W$
>
> A common challenge in the field is learning to recognize whether a 3D
> map is consistent with a given resolution estimate. Confusing, for
> example, a 4 Å map with an 8 Å map can lead to substantial time loss
> during model building and interpretation. This game was created to help
> users develop an intuition for the structural features visible across
> the range of resolutions typically obtained in cryo-EM/ET.
>
> It is aimed mainly at students and beginners, but others may also find
> it fun or useful as a quick training exercise.
>
> I should note that I am fully aware that noise plays an important role
> in real cryo-EM/ET data, and this first version of the game does not yet
> include noise.
>
> Feedback is very welcome. Please feel free to share it with anyone who
> might be interested.
>
> Best regards,
>
> Leandro.
>
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