[3dem] New game to learn/train cryo-EM/ET map resolution recognition

Leandro F. Estrozi leandro.estrozi at ibs.fr
Tue Apr 21 09:44:44 PDT 2026


Dear colleagues,

I am pleased to share a new online training game designed for newcomers 
in structural biology, with a focus on cryo-EM and cryo-ET map 
interpretation:

https://urldefense.com/v3/__https://rico.ibs.fr/helixplorer/resolution/__;!!Mih3wA!EJvDy_wVZYtD-rptRWtrUxbq7A8pGA1ZjbK_kAX9nYpXHYtdekjFvrioD4obUpLP_o_2rpttEOrdDSTtQBS4juXqBm9W$ 

A common challenge in the field is learning to recognize whether a 3D 
map is consistent with a given resolution estimate. Confusing, for 
example, a 4 Å map with an 8 Å map can lead to substantial time loss 
during model building and interpretation. This game was created to help 
users develop an intuition for the structural features visible across 
the range of resolutions typically obtained in cryo-EM/ET.

It is aimed mainly at students and beginners, but others may also find 
it fun or useful as a quick training exercise.

I should note that I am fully aware that noise plays an important role 
in real cryo-EM/ET data, and this first version of the game does not yet 
include noise.

Feedback is very welcome. Please feel free to share it with anyone who 
might be interested.

Best regards,

Leandro.



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