[3dem] Postdoc opportunity in the Wright lab at UW-Madison

[Elizabeth R Wright]

POSTDOCTORAL RESEARCH ASSOCIATE POSITION, UNIVERSITY OF WISCONSIN, MADISON

An NIH-funded postdoctoral research associate position is available in the Wright laboratory at the University of Wisconsin, Madison starting fall/winter 2023/2024. Research in the lab is broadly focused on structural biology related to neurodegenerative diseases, cell biology, host-pathogen relationships among various bacterial and viral pathogens, and the development of cryo-imaging technologies in the areas of correlative microscopy, cryo-FIB, and substrate patterning.
The postdoctoral research associate joining the Wright lab will be a part of an exciting NIH-funded collaborative research initiative focused on the ‘Structural Biology of Alpha-Synuclein in Lewy Body Dementia.’ The research investigations are a synergy between the Kotzbauer group<https://urldefense.com/v3/__http://www.kotzbauerlab.wustl.edu/__;!!Mih3wA!Cml14d6gS5cR2VfVO7ROeI8rcbRjTB3Nl220uVneQH5ftfikZ1gP4xyl19mwgdEQ0dZf4-CQ7v3yGVYkXNSw3hI$ > at Washington University in St. Louis, the Rienstra group<https://urldefense.com/v3/__https://rienstralab.biochem.wisc.edu/__;!!Mih3wA!Cml14d6gS5cR2VfVO7ROeI8rcbRjTB3Nl220uVneQH5ftfikZ1gP4xyl19mwgdEQ0dZf4-CQ7v3yGVYkaZ2jGMg$ > at UW-Madison, and the Wright group<https://urldefense.com/v3/__https://wrightlab.wisc.edu/__;!!Mih3wA!Cml14d6gS5cR2VfVO7ROeI8rcbRjTB3Nl220uVneQH5ftfikZ1gP4xyl19mwgdEQ0dZf4-CQ7v3yGVYkJgSeU8k$ > at UW-Madison. Overall, we are interested in understanding alpha-synuclein (Asyn) fibril structure in Lewy body dementia (LBD) to guide the development of Asyn-targeted therapies and imaging agents. Specifically, the research combines use of cryo-EM; correlative microscopy; molecular, cellular, and organismal approaches; and solid-state NMR (SSNMR) to investigate specific structure-function relationships associated with alpha-synuclein and Lewy body dementia.
Candidates should have an interest in structural biology, neurobiology, neurodegeneration, and should enjoy working as part of a cross-disciplinary, active research team. Background experience in one (or more) of the following fields is desirable, but not required: neurobiology, molecular biology, (cryo-) electron microscopy, and/or image processing/analysis techniques.

The wet laboratory is in the Biochemistry Department and is fully equipped for all aspects of molecular biology, protein biochemistry, and cryo-EM. The Wright lab has access to state-of-the-art cryo-EM resources in the UW-Madison Cryo-EM Research Center (https://urldefense.com/v3/__https://cryoem.wisc.edu__;!!Mih3wA!Cml14d6gS5cR2VfVO7ROeI8rcbRjTB3Nl220uVneQH5ftfikZ1gP4xyl19mwgdEQ0dZf4-CQ7v3yGVYkEgzUa3o$ ). This postdoctoral position is supported by the NIH. The position provides opportunities for interdisciplinary collaborations with scientists at the University of Wisconsin-Madison, Wash U., and other partners.

Applicants should include a cover letter describing research experience and interests, curriculum vitae, and names and contact information for three references.

Dr. Elizabeth R. Wright
Department of Biochemistry
University of Wisconsin
Madison, WI 53706
erwright2 at wisc.edu<mailto:erwright2 at wisc.edu>
Website: https://urldefense.com/v3/__https://wrightlab.wisc.edu__;!!Mih3wA!Cml14d6gS5cR2VfVO7ROeI8rcbRjTB3Nl220uVneQH5ftfikZ1gP4xyl19mwgdEQ0dZf4-CQ7v3yGVYk-FdP4Bw$ 

Applications will be reviewed as they are received and until the position is filled.
UW-Madison is an affirmative action/equal opportunity employer.


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Elizabeth R. Wright, PhD
Professor, Department of Biochemistry
Cryo-Electron Microscopy Research Center
Midwest Center for Cryo-Electron Tomography
University of Wisconsin-Madison
Morgridge Institute for Research
erwright2 at wisc.edu<mailto:erwright2 at wisc.edu>

Assistant: Alex Cotten
cotten at wisc.edu<mailto:cotten at wisc.edu>


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