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<p class="MsoNormal" style="text-autospace:none"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">POSTDOCTORAL RESEARCH ASSOCIATE POSITION, UNIVERSITY OF WISCONSIN, MADISON<o:p></o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">An NIH-funded postdoctoral research associate position is available in the Wright laboratory at the University of Wisconsin, Madison starting
fall/winter 2023/2024. Research in the lab is broadly focused on structural biology related to neurodegenerative diseases, cell biology, host-pathogen relationships among various bacterial and viral pathogens, and the development of cryo-imaging technologies
in the areas of correlative microscopy, cryo-FIB, and substrate patterning.<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">The postdoctoral research associate joining the Wright lab will be a part of an exciting NIH-funded collaborative
research initiative focused on the ‘Structural Biology of Alpha-Synuclein in Lewy Body Dementia.’ The research investigations are a synergy between the
<a href="https://urldefense.com/v3/__http://www.kotzbauerlab.wustl.edu/__;!!Mih3wA!Cml14d6gS5cR2VfVO7ROeI8rcbRjTB3Nl220uVneQH5ftfikZ1gP4xyl19mwgdEQ0dZf4-CQ7v3yGVYkXNSw3hI$">Kotzbauer group</a> at Washington University in St. Louis, the
<a href="https://urldefense.com/v3/__https://rienstralab.biochem.wisc.edu/__;!!Mih3wA!Cml14d6gS5cR2VfVO7ROeI8rcbRjTB3Nl220uVneQH5ftfikZ1gP4xyl19mwgdEQ0dZf4-CQ7v3yGVYkaZ2jGMg$">Rienstra group</a> at UW-Madison, and the
<a href="https://urldefense.com/v3/__https://wrightlab.wisc.edu/__;!!Mih3wA!Cml14d6gS5cR2VfVO7ROeI8rcbRjTB3Nl220uVneQH5ftfikZ1gP4xyl19mwgdEQ0dZf4-CQ7v3yGVYkJgSeU8k$">Wright group</a> at UW-Madison. Overall, we are interested in understanding
</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif">alpha-synuclein (Asyn) fibril structure in Lewy body dementia (LBD) to guide the development of Asyn-targeted therapies and imaging agents<span style="color:black">.
</span></span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">Specifically, the research combines use of cryo-EM; correlative microscopy; molecular, cellular, and organismal approaches; and solid-state NMR (SSNMR) to investigate specific
structure-function relationships associated with alpha-synuclein and Lewy body dementia.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">Candidates should have an interest in structural biology, neurobiology, neurodegeneration, and should enjoy working as part of a cross-disciplinary,
active research team. Background experience in one (or more) of the following fields is desirable, but not required: neurobiology, molecular biology, (cryo-) electron microscopy, and/or image processing/analysis techniques.</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">The wet laboratory is in the Biochemistry Department and is fully equipped for all aspects of molecular biology, protein biochemistry,
and cryo-EM. The Wright lab has access to state-of-the-art cryo-EM resources in the UW-Madison Cryo-EM Research Center (<a href="https://urldefense.com/v3/__https://cryoem.wisc.edu__;!!Mih3wA!Cml14d6gS5cR2VfVO7ROeI8rcbRjTB3Nl220uVneQH5ftfikZ1gP4xyl19mwgdEQ0dZf4-CQ7v3yGVYkEgzUa3o$"><span style="color:black">https://cryoem.wisc.edu</span></a>).
</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">This postdoctoral position is supported by the NIH. The position provides opportunities for interdisciplinary collaborations with scientists at the University of Wisconsin-Madison,
Wash U., and other partners.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">Applicants should include a cover letter describing research experience and interests, curriculum vitae, and names and contact information
for three references.<br>
<br>
Dr. Elizabeth R. Wright<br>
Department of Biochemistry<o:p></o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">University of Wisconsin<br>
Madison, WI 53706<br>
<u><a href="mailto:erwright2@wisc.edu"><span style="color:black">erwright2@wisc.edu</span></a><br>
</u>Website: <u><a href="https://urldefense.com/v3/__https://wrightlab.wisc.edu__;!!Mih3wA!Cml14d6gS5cR2VfVO7ROeI8rcbRjTB3Nl220uVneQH5ftfikZ1gP4xyl19mwgdEQ0dZf4-CQ7v3yGVYk-FdP4Bw$"><span style="color:black">https://wrightlab.wisc.edu</span></a><br>
</u><br>
Applications will be reviewed as they are received and until the position is filled.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black">UW-Madison is an affirmative action/equal opportunity employer.</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="mso-ligatures:none">----<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-ligatures:none">Elizabeth R. Wright, PhD</span><span style="color:black;mso-ligatures:none"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-ligatures:none">Professor, Department of Biochemistry</span><span style="color:black;mso-ligatures:none"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-ligatures:none">Cryo-Electron Microscopy Research Center</span><span style="color:black;mso-ligatures:none"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-ligatures:none">Midwest Center for Cryo-Electron Tomography</span><span style="color:black;mso-ligatures:none"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-ligatures:none">University of Wisconsin-Madison</span><span style="color:black;mso-ligatures:none"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-ligatures:none">Morgridge Institute for Research</span><span style="color:black;mso-ligatures:none"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-ligatures:none"><a href="mailto:erwright2@wisc.edu" title="mailto:erwright2@wisc.edu"><span style="color:#0086F0">erwright2@wisc.edu</span></a></span><span style="color:black;mso-ligatures:none"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-ligatures:none"> </span><span style="color:black;mso-ligatures:none"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-ligatures:none">Assistant: Alex Cotten</span><span style="color:black;mso-ligatures:none"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-ligatures:none"><a href="mailto:cotten@wisc.edu" title="mailto:cotten@wisc.edu"><span style="color:#0086F0">cotten@wisc.edu</span></a></span><span style="color:black;mso-ligatures:none"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-ligatures:none"><o:p> </o:p></span></p>
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