[3dem] Senior Scientist (Protein Engineer) position at ModeX Therapeutics (Weston, MA, USA)

[Yuri Iozzo]

Hi everyone,
I am looking for an experienced protein engineer to join my group.

Please, apply on the website, but also send me a copy of your CV.
Senior Scientist (Structural Biology) in Natick, Massachusetts | Careers at Modex Therapeutics (icims.com)<https://urldefense.com/v3/__https://careers-modex.icims.com/jobs/4126/senior-scientist-*28structural-biology*29/job__;JSU!!Mih3wA!FJ-6osXNjKIC6v2FlDppNpBW6jlRa46SCRrSH-wo8nhJ2wG4HE44b42R-XFfHFs3Xboc_jRqwSKqez6u9y6AkPOm$ >

Job description:
Senior Scientist (Protein Engineering)
Company
ModeX is a clinical-stage biopharmaceutical company developing next-generation multispecific antibodies and vaccines for cancer and infectious disease. ModeX's modular antibody platforms unite the power of multiple biologic components in a single molecule to create multispecific antibodies with greater versatility and potency to fight complex disease than traditional approaches. Our pipeline includes candidates against both solid and hematological tumors as well as several of the world's most pressing viral threats. Our founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients.
Job Summary
ModeX is looking for an experienced protein engineer with strong background in structural biology, protein generation, liability mitigation and design. This role mainly focuses on facilitating multiple projects through early engineering interventions during the candidate selection and development. Occasional outsourcing of X-ray and cryo-EM structure solving efforts is expected as well as managing connections with several CROs.
Key accountability and responsibilities include:

  *   Project analysis and making pro-active engineering initiatives,
  *   Rational engineering and software-assisted engineering,
  *   Antibody design including format selection, linkers, mutations, liability removal,
  *   Structure generation with AF2 and structure analysis,
  *   Managing structural biology CROs,
  *   Structure solving through outsourcing and analysis of results,
  *   Molecular dynamics and analysis of results,
  *   Supporting multiple projects at a time.
Key qualifications:

  *   M.Sc. or Ph.D. in chemistry, biology, or other relevant discipline,
  *   Minimum 2 years of prior industry experience (the hiring manager will consider postdoc years in lieu of industry experience),
  *   Strong hands-on protein design and engineering skills,
  *   Experience with protein production and purification,
  *   Solid background in structural biology with a publication record,
  *   Proficiency with protein design, engineering, and structural biology software (PyMol, Chimera, Coot, Schrodinger etc),
  *   Excellent presentation skills.


Best,
Yuri
_______
Yuri Iozzo, PhD (eqv), Associate Director of Digital Biology
ModeX Therapeutics
20 Riverside Rd, Weston, MA 02493
E: Yuri.Iozzo at ModeXTX.com<mailto:Yuri.Iozzo at ModeXTX.com>
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