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<body lang="EN-US" link="#0563C1" vlink="#954F72" style="word-wrap:break-word">
<div class="WordSection1">
<p class="MsoNormal">Hi everyone,<o:p></o:p></p>
<p class="MsoNormal">I am looking for an experienced protein engineer to join my group.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Please, apply on the website, but also send me a copy of your CV.<o:p></o:p></p>
<p class="MsoNormal"><a href="https://urldefense.com/v3/__https://careers-modex.icims.com/jobs/4126/senior-scientist-*28structural-biology*29/job__;JSU!!Mih3wA!FJ-6osXNjKIC6v2FlDppNpBW6jlRa46SCRrSH-wo8nhJ2wG4HE44b42R-XFfHFs3Xboc_jRqwSKqez6u9y6AkPOm$">Senior Scientist (Structural Biology) in Natick, Massachusetts | Careers at Modex Therapeutics (icims.com)</a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><u>Job description:<o:p></o:p></u></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:18.0pt">Senior Scientist (Protein Engineering)<o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:12.0pt">Company <o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-top:12.0pt;text-align:justify"><span style="font-size:12.0pt">ModeX is a clinical-stage biopharmaceutical company developing next-generation multispecific antibodies and vaccines for cancer and infectious disease. ModeX's
modular antibody platforms unite the power of multiple biologic components in a single molecule to create multispecific antibodies with greater versatility and potency to fight complex disease than traditional approaches. Our pipeline includes candidates against
both solid and hematological tumors as well as several of the world's most pressing viral threats. Our founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients.
<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:12.0pt">Job Summary<o:p></o:p></span></b></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:12.0pt">ModeX is looking for an experienced protein engineer with strong background in structural biology, protein generation, liability mitigation and design. This role mainly focuses on
facilitating multiple projects through early engineering interventions during the candidate selection and development. Occasional outsourcing of X-ray and cryo-EM structure solving efforts is expected as well as managing connections with several CROs.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:12.0pt">Key accountability and responsibilities include:<u><o:p></o:p></u></span></b></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoListParagraphCxSpFirst" style="margin-left:0in;mso-add-space:auto;mso-list:l3 level1 lfo3">
<span style="font-size:12.0pt;line-height:105%">Project analysis and making pro-active engineering initiatives,<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;mso-list:l3 level1 lfo3">
<span style="font-size:12.0pt;line-height:105%">Rational engineering and software-assisted engineering,<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;mso-list:l3 level1 lfo3">
<span style="font-size:12.0pt;line-height:105%">Antibody design including format selection, linkers, mutations, liability removal,<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;mso-list:l3 level1 lfo3">
<span style="font-size:12.0pt;line-height:105%">Structure generation with AF2 and structure analysis,<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;mso-list:l3 level1 lfo3">
<span style="font-size:12.0pt;line-height:105%">Managing structural biology CROs,<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;mso-list:l3 level1 lfo3">
<span style="font-size:12.0pt;line-height:105%">Structure solving through outsourcing and analysis of results,<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;mso-list:l3 level1 lfo3">
<span style="font-size:12.0pt;line-height:105%">Molecular dynamics and analysis of results,<o:p></o:p></span></li><li class="MsoListParagraphCxSpLast" style="margin-left:0in;mso-add-space:auto;mso-list:l3 level1 lfo3">
<span style="font-size:12.0pt;line-height:105%">Supporting multiple projects at a time.<o:p></o:p></span></li></ul>
<p class="MsoNormal"><b><span style="font-size:12.0pt">Key qualifications:<o:p></o:p></span></b></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoListParagraphCxSpFirst" style="margin-left:0in;mso-add-space:auto;mso-list:l0 level1 lfo6">
<span style="font-size:12.0pt;line-height:105%">M.Sc. or Ph.D. in chemistry, biology, or other relevant discipline,<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;mso-list:l0 level1 lfo6">
<span style="font-size:12.0pt;line-height:105%">Minimum 2 years of prior industry experience (the hiring manager will consider postdoc years
<i>in lieu</i> of industry experience),<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;mso-list:l0 level1 lfo6">
<span style="font-size:12.0pt;line-height:105%">Strong hands-on protein design and engineering skills,<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;mso-list:l0 level1 lfo6">
<span style="font-size:12.0pt;line-height:105%">Experience with protein production and purification,<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;mso-list:l0 level1 lfo6">
<span style="font-size:12.0pt;line-height:105%">Solid background in structural biology with a publication record,<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-left:0in;mso-add-space:auto;mso-list:l0 level1 lfo6">
<span style="font-size:12.0pt;line-height:105%">Proficiency with protein design, engineering, and structural biology software (PyMol, Chimera, Coot, Schrodinger etc),<o:p></o:p></span></li><li class="MsoListParagraphCxSpLast" style="margin-left:0in;mso-add-space:auto;mso-list:l0 level1 lfo6">
<span style="font-size:12.0pt;line-height:105%">Excellent presentation skills.<o:p></o:p></span></li></ul>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span style="color:#44546A">Best,</span><span style="color:#44546A;mso-ligatures:none"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:12.0pt;font-family:"Calibri Light",sans-serif">Yuri
<o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:red">_______</span></b><b><span style="font-size:12.0pt;font-family:"Ink Free";color:red"><o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Gill Sans MT",sans-serif;color:#44546A">Yuri Iozzo, PhD (eqv), Associate Director of Digital Biology
<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:9.0pt;font-family:"Gill Sans MT",sans-serif;color:#44546A">ModeX Therapeutics</span></b><span style="font-size:9.0pt;font-family:"Gill Sans MT",sans-serif;color:#44546A">
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Gill Sans MT",sans-serif;color:#44546A">20 Riverside Rd, Weston, MA 02493<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Gill Sans MT",sans-serif;color:#44546A">E:
</span><a href="mailto:Yuri.Iozzo@ModeXTX.com"><span style="font-size:9.0pt;font-family:"Gill Sans MT",sans-serif">Yuri.Iozzo@ModeXTX.com</span></a><span style="font-size:9.0pt;font-family:"Gill Sans MT",sans-serif;color:#44546A"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#1F3864;mso-ligatures:none"><img border="0" width="99" height="43" style="width:1.0312in;height:.4479in" id="Picture_x0020_3" src="cid:image001.png@01DA117E.6D6889D0" alt="A picture containing logo
Description automatically generated"></span><span style="color:#1F3864"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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