[3dem] 3-year Biochemistry/Structural Postdoc position at Imperial College London

[Speck, Christian]

Are you interested in mechanistic research using biochemical and structural approaches to uncover DNA replication control principles that are misregualted in cancer?
So are we! Join us for a 3-year postdoc position (£45,593 - £49,305 per annum) at Imperial College London (one of the top 10 universities in the world)

The Science case:
It is unknown how human DNA replication origins are chosen or how they can be controlled, but this understanding has enormous relevance for genome stability and cancer biology. Thus, we aim to research 1.) how DNA replication origins are specified through epigenetic mechanisms and specific recruitment factors and 2.) how DNA replication is regulated to allow faithful DNA replication. We will further ask how mutations in these processes contribute to genome instability and whether they are enriched in cancer.

How can this be done?
We have recently reconstituted human DNA helicase loading using purified proteins. The successful candidate will use the system to investigate the targeting, assembly, function and regulation of human helicase loading using biochemical/biophysical tools. Genomewide AlphaFold screens will allow us to identify novel factors involved in this process. Consequently, these interactions will be characterised by biochemical and structural approaches in order to understand their function in helicase loading. This work will contribute to a fundamental understanding of DNA replication and how this process is regulated and implemented. Given the pivotal role of successful helicase loading on tumorigenesis, it will also direct us toward novel therapeutic targets.

Who we look for:
We seek a creative researcher who enjoys tackling ambitious research questions. You should be experienced in protein expression, purification of multi-subunit complexes and biochemical assays. Enjoying methods development would be a big plus. The candidate should relish discussing science, be social and good at networking. This project is ideal for candidates who want to switch fields and learn cryo-EM. Prior experience in the supervision of master students would be welcome. Professor Speck will mentor you in grant writing, networking and publishing. Indeed, the scientific framework and the support by Prof. Speck means that the candidates are well placed for a successful transition into independence.

How to apply:
For full details of this post (Job Description and Person Specification) and to complete an online application, click the link below and upload your CV and cover letter detailing your motivation for the position. The position is available immediately, but candidates can start within 6 months.

Biochemistry/Structural position:
Research Associate | Jobs | Imperial College London<https://urldefense.com/v3/__https://www.imperial.ac.uk/jobs/description/MED04213/research-associate__;!!Mih3wA!FhTDjzvT72WtGA_CmzM0HM3NUy8TwWKEpHK_wcptyZxJEfvdMyvrhKyeNy-UDFX3QuZ_sTTtRofUOO_Ugs2VTvrCBiJ6DQ$ >
Closing date: January 3rd
Interested candidates can contact Christian via email @ chris.speck at imperial.ac.uk<mailto:chris.speck at imperial.ac.uk>


__________________________________________

Professor Christian Speck, PhD, FRSB
Chair in Genome Biochemistry & Molecular Biology

Institute of Clinical Sciences (LMS building 2.14B)
Faculty of Medicine
Imperial College London
Hammersmith Hospital Campus
Du Cane Road
London W12 0HS

Mobile: 0044 796 181 5557
email: christian.speck at imperial.ac.uk<mailto:christian.speck at imperial.ac.uk>
website: https://urldefense.com/v3/__http://www.specklab.com__;!!Mih3wA!FhTDjzvT72WtGA_CmzM0HM3NUy8TwWKEpHK_wcptyZxJEfvdMyvrhKyeNy-UDFX3QuZ_sTTtRofUOO_Ugs2VTvrs7_TVWQ$ <https://urldefense.com/v3/__http://www.specklab.com/__;!!Mih3wA!FhTDjzvT72WtGA_CmzM0HM3NUy8TwWKEpHK_wcptyZxJEfvdMyvrhKyeNy-UDFX3QuZ_sTTtRofUOO_Ugs2VTvoi8r1Bfw$ >

My personal pronouns are he/him
Please don't feel obliged to reply to this email outside your normal working hours

    [Discovery Programme Awards | Cancer Research UK] [cid:image002.png at 01DA334F.886A1EE0]  [CBC28AC5]

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