<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0cm;
font-size:11.0pt;
font-family:"Calibri",sans-serif;
mso-fareast-language:EN-US;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:#0563C1;
text-decoration:underline;}
span.EmailStyle17
{mso-style-type:personal-compose;
font-family:"Calibri",sans-serif;
color:windowtext;}
.MsoChpDefault
{mso-style-type:export-only;
mso-fareast-language:EN-US;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:72.0pt 72.0pt 72.0pt 72.0pt;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1027" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="EN-GB" link="#0563C1" vlink="#954F72" style="word-wrap:break-word">
<div class="WordSection1">
<p class="MsoNormal">Are you interested in mechanistic research using biochemical and structural approaches to uncover DNA replication control principles that are misregualted in cancer?<o:p></o:p></p>
<p class="MsoNormal">So are we! Join us for a 3-year postdoc position (£45,593 – £49,305 per annum) at Imperial College London (one of the top 10 universities in the world)<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b>The Science case:<o:p></o:p></b></p>
<p class="MsoNormal">It is unknown how human DNA replication origins are chosen or how they can be controlled, but this understanding has enormous relevance for genome stability and cancer biology. Thus, we aim to research 1.) how DNA replication origins are
specified through epigenetic mechanisms and specific recruitment factors and 2.) how DNA replication is regulated to allow faithful DNA replication. We will further ask how mutations in these processes contribute to genome instability and whether they are
enriched in cancer.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b>How can this be done?</b><o:p></o:p></p>
<p class="MsoNormal">We have recently reconstituted human DNA helicase loading using purified proteins. The successful candidate will use the system to investigate the targeting, assembly, function and regulation of human helicase loading using biochemical/biophysical
tools. Genomewide AlphaFold screens will allow us to identify novel factors involved in this process. Consequently, these interactions will be characterised by biochemical and structural approaches in order to understand their function in helicase loading.
This work will contribute to a fundamental understanding of DNA replication and how this process is regulated and implemented. Given the pivotal role of successful helicase loading on tumorigenesis, it will also direct us toward novel therapeutic targets. <o:p></o:p></p>
<p class="MsoNormal"><b><o:p> </o:p></b></p>
<p class="MsoNormal"><b>Who we look for:</b><o:p></o:p></p>
<p class="MsoNormal">We seek a creative researcher who enjoys tackling ambitious research questions. You should be experienced in protein expression, purification of multi-subunit complexes and biochemical assays. Enjoying methods development would be a big
plus. The candidate should relish discussing science, be social and good at networking. This project is ideal for candidates who want to switch fields and learn cryo-EM. Prior experience in the supervision of master students would be welcome. Professor Speck
will mentor you in grant writing, networking and publishing. Indeed, the scientific framework and the support by Prof. Speck means that the candidates are well placed for a successful transition into independence.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b>How to apply:</b><o:p></o:p></p>
<p class="MsoNormal">For full details of this post (Job Description and Person Specification) and to complete an online application, click the link below and upload your CV and cover letter detailing your motivation for the position. The position is available
immediately, but candidates can start within 6 months.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b>Biochemistry/Structural position:</b><o:p></o:p></p>
<p class="MsoNormal"><a href="https://urldefense.com/v3/__https://www.imperial.ac.uk/jobs/description/MED04213/research-associate__;!!Mih3wA!FhTDjzvT72WtGA_CmzM0HM3NUy8TwWKEpHK_wcptyZxJEfvdMyvrhKyeNy-UDFX3QuZ_sTTtRofUOO_Ugs2VTvrCBiJ6DQ$">Research Associate | Jobs | Imperial College London</a><o:p></o:p></p>
<p class="MsoNormal">Closing date: <b>January 3rd</b><o:p></o:p></p>
<p class="MsoNormal">Interested candidates can contact <b>Christian</b> via email @ <a href="mailto:chris.speck@imperial.ac.uk">chris.speck@imperial.ac.uk</a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><i><span style="color:#1F497D;mso-fareast-language:DE">__________________________________________</span></i><i><span style="font-size:12.0pt;color:#1F497D;mso-fareast-language:DE"><o:p></o:p></span></i></p>
<p class="MsoNormal"><span lang="EN-US" style="color:#1F497D;mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><i><span style="color:#1F3864;mso-fareast-language:DE">Professor Christian Speck, PhD, FRSB<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span style="color:#1F3864;mso-fareast-language:DE">Chair in Genome Biochemistry & Molecular Biology</span></i><span style="color:#1F3864;mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="color:#1F3864;mso-fareast-language:DE"><o:p> </o:p></span></i></p>
<p class="MsoNormal"><span style="color:#44546A;mso-fareast-language:EN-GB">Institute of Clinical Sciences (LMS building 2.14B)<br>
Faculty of Medicine<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#44546A;mso-fareast-language:EN-GB">Imperial College London<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#44546A;mso-fareast-language:EN-GB">Hammersmith Hospital Campus<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#44546A;mso-fareast-language:EN-GB">Du Cane Road<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#44546A;mso-fareast-language:EN-GB">London W12 0HS<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="color:#1F3864;mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><i><span style="color:#1F3864;mso-fareast-language:DE">Mobile</span></i><span style="color:#1F3864;mso-fareast-language:DE">: 0044 796 181 5557<o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="color:#1F3864;mso-fareast-language:DE">email</span></i><span style="color:#1F3864;mso-fareast-language:DE">:
</span><span style="color:#1F3864;mso-fareast-language:EN-GB"><a href="mailto:christian.speck@imperial.ac.uk"><span style="color:#1F3864;mso-fareast-language:DE">christian.speck@imperial.ac.uk</span></a></span><span style="color:#1F3864;mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-size:10.0pt;color:#1F3864;mso-fareast-language:DE">website</span></i><span style="font-size:10.0pt;color:#1F3864;mso-fareast-language:DE">:
</span><span style="color:#1F3864;mso-fareast-language:EN-GB"><a href="https://urldefense.com/v3/__http://www.specklab.com/__;!!Mih3wA!FhTDjzvT72WtGA_CmzM0HM3NUy8TwWKEpHK_wcptyZxJEfvdMyvrhKyeNy-UDFX3QuZ_sTTtRofUOO_Ugs2VTvoi8r1Bfw$"><span style="font-size:10.0pt;color:#1F3864;mso-fareast-language:DE">www.specklab.com</span></a></span><span style="font-size:10.0pt;color:#1F3864;mso-fareast-language:DE">
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#1F3864;mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="color:#1F3864;mso-fareast-language:EN-GB">My personal pronouns are he/him</span><span style="color:#1F3864;mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;color:#1F3864;mso-fareast-language:EN-GB">Please don't feel obliged to reply to this email outside your normal working hours</span><span style="font-size:10.0pt;color:#1F3864;mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#1F497D;mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="color:#1F497D;mso-fareast-language:EN-GB"> </span><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f">
<v:stroke joinstyle="miter" />
<v:formulas>
<v:f eqn="if lineDrawn pixelLineWidth 0" />
<v:f eqn="sum @0 1 0" />
<v:f eqn="sum 0 0 @1" />
<v:f eqn="prod @2 1 2" />
<v:f eqn="prod @3 21600 pixelWidth" />
<v:f eqn="prod @3 21600 pixelHeight" />
<v:f eqn="sum @0 0 1" />
<v:f eqn="prod @6 1 2" />
<v:f eqn="prod @7 21600 pixelWidth" />
<v:f eqn="sum @8 21600 0" />
<v:f eqn="prod @7 21600 pixelHeight" />
<v:f eqn="sum @10 21600 0" />
</v:formulas>
<v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect" />
<o:lock v:ext="edit" aspectratio="t" />
</v:shapetype><v:shape id="AutoShape_x0020_1" o:spid="_x0000_s1026" type="#_x0000_t75" alt="Discovery Programme Awards | Cancer Research UK" style='width:24pt;height:24pt;visibility:visible;mso-left-percent:-10001;mso-top-percent:-10001;mso-position-horizontal:absolute;mso-position-horizontal-relative:char;mso-position-vertical:absolute;mso-position-vertical-relative:line;mso-left-percent:-10001;mso-top-percent:-10001'>
<w:wrap type="none"/>
<w:anchorlock/>
</v:shape><![endif]--><![if !vml]><img width="32" height="32" style="width:.3333in;height:.3333in" src="cid:image001.png@01DA334F.886A1EE0" alt="Discovery Programme Awards | Cancer Research UK" v:shapes="AutoShape_x0020_1"><![endif]><span style="mso-fareast-language:EN-GB"><img border="0" width="222" height="86" style="width:2.3166in;height:.9in" id="_x0000_i1026" src="cid:image002.png@01DA334F.886A1EE0"><span style="color:#1F497D">
</span><img border="0" width="167" height="94" style="width:1.7416in;height:.9833in" id="Picture_x0020_2" src="cid:image003.jpg@01DA334F.886A1EE0" alt="CBC28AC5"></span><span style="color:#1F497D;mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
</body>
</html>