[3dem] Senior Research Associate position at UTSW Medical Center, O'Donnell Brain Institute

[Sarah Shahmoradian]

Dear All,



I am excited to announce a joint Senior Research Associate position with my
lab and Prof. William Dauer’s lab (head of the O’Donnell Brain Institute)
at UT Southwestern Medical Center (UTSW) here in Dallas, Texas. Ad is
below. Please spread the word, and kindly forward to potential candidates.
Thank you!


Stay well, best regards,
Sarah



A Senior Research Associate position (with opportunity for advancement) is
immediately available to investigate neuronal nuclear pore complex (NPC)
and nuclear membrane during development and in neurological disease.

This project will be pursued jointly by the Shahmoradian lab and Dauer lab
at UT Southwestern Medical Center.

> The Shahmoradian lab develops and applies cryo-electron tomography and
correlative light and electron microscopy technologies to study the
macromolecular basis of protein aggregation and membrane remodeling in
neurological disease.

> The Dauer lab has identified a defect of nuclear pore complex biogenesis
and insertion in neurons in dystonia. They have generated a suite of novel
reagents to probe this disease related dysfunction and to study the
neuronal nuclear membrane more generally.

The successful candidate will take an active role in defining and driving
future studies of nuclear pore complex abnormalities and nuclear envelope
remodeling research being jointly pursued by these labs. Main methods are
cryo-focused ion beam specimen preparations, cryo-electron tomography and
3D processing/sub-tomogram averaging, together with correlative
light/electron microscopy.

*Requirements:*

   - Ph.D. in life science or engineering (or due to complete within 6
   months), or a Masters +5 years lab experience, or a Bachelor’s +6 years lab
   experience.
   - Publication record with original contributions
   - Prior experience with cryo-electron microscopy or 3D electron
   microscopy (SBF-SEM, FIB-SEM, etc), and/or super-resolution light
   microscopy techniques (STED/SIM/STORM/PALM…)


*Working environment:*

Successful candidates will benefit from excellent infrastructure and
growing resources available here at UTSW:

   - Newly purchased Thermo Fisher Aquilos II cryoFIB/SEM equipped with
   both internal cryo-widefield and external Leica cryo-confocal fluorescence
   microscopes
   - 2 Titan Krios cryo-electron microscopes with direct electron
   detectors, including one with the latest generation cold field emission gun
   and Selectris-X energy filter (other has Volta phase plate and BioQuantum
   energy filter)
   - Talos Arctica cryo-electron microscope with K3 direct electron
   detector and Volta phase plate
   - Talos Glacios cryo-electron microscope with Falcon direct electron
   detector and Ceta-D camera
   - Custom-engineered, super-resolution, light-sheet and cleared tissue
   microscopes
   - UTSW Whole Brain Microscopy Facility with several high-throughput
   microscopes including two state-of-the-art multi-photon microscopes with
   integrated precision vibratomes
   - UTSW Green Center for Systems Biology with ~25 isolated microscope
   development bays equipped with optical tables
   - UTSW Department of Bioinformatics with BioHPC, a high-performance
   computing and storage facility equipped with ~1000 CPU and ~120 GPU nodes
   connected to 50 PB of storage for in-house data analysis (All instruments
   have direct mounts to this computing infrastructure)


*University highlights:*

   - Highly collaborative and inclusive environment encompassing the entire
   spectrum of basic, translational, and clinical research
   - Six Nobel Prize Winners and 25 members of the National Academy of
   Sciences
   - Ranked No. 1 in the world among healthcare institutions in biomedical
   sciences (Nature Index 2019)
   - Several employee benefits including free health insurance for
   full-time staff, and excellent coverage for dependents.

*Living environment:*

The Dallas-Fort Worth Metroplex is home to:

   - Top educational school systems in Texas and the nation
   - Dallas Arts District, the largest contiguous urban arts district in
   the United States, covering contiguous ~120 acres (0.5 square kilometer)
   - “Deep Ellum”, the live music capital of North Texas and a hub for the
   performing arts from theater to comedy
   - Several parks and lakes great for boating and camping
   - Multitude of great dining and shopping options
   - Central location in the US, with easy access to major international
   airport and a smaller national airport


To apply, please email *sarah.shahmoradian at utsouthwestern.edu
<sarah.shahmoradian at utsouthwestern.edu>* with your cover letter and CV.



[image: image.png]

*Sarah Shahmoradian, PhD*

Assistant Professor

Center for Alzheimer’s and Neurodegenerative Diseases

Department of Biophysics

Peter O’Donnell Jr. Brain Institute
UT Southwestern Medical Center

*Mailing address:*

North Campus NL10-140

Mail Code 8594

UT Southwestern Medical Center

5323 Harry Hines Blvd

Dallas, TX 75390-8594

[image: image.png]

*UT** Southwestern*

Medical Center

The future of medicine, today.
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20220911/f9d6cb3e/attachment.html>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image.png
Type: image/png
Size: 109 bytes
Desc: not available
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20220911/f9d6cb3e/attachment.png>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image.png
Type: image/png
Size: 109 bytes
Desc: not available
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20220911/f9d6cb3e/attachment-0001.png>