[3dem] Cryo-EM Scientist position at leadXpro (Villigen, Switzerland)

[Mathieu Botte]

Dear all,

leadXpro is a biotech company located on the Paul Scherrer Institute (PSI) campus in Villigen, Switzerland. The company is specialized in solving structures of membrane protein drug targets for drug discovery.

We have an open position for a scientist to work in the EM team. The job description can be found below, on the leadXpro website (https://urldefense.proofpoint.com/v2/url?u=https-3A__leadxpro.com_scientist-2Dcryo-2Delectron-2Dmicroscopy-2D100_&d=DwIF-g&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=g4z6bk6Ef4Ho7LRP9AbFGUliRFCScyYGBGgeRKRrDhfp3lHujDFP_jZZ0HKD0lCG&s=GTavSlfYn8CA4Rq3okh_-482Z-VHZMqN43xx-K6NSPI&e= ) and on LinkedIn (https://urldefense.proofpoint.com/v2/url?u=https-3A__www.linkedin.com_jobs_view_3043291555&d=DwIF-g&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=g4z6bk6Ef4Ho7LRP9AbFGUliRFCScyYGBGgeRKRrDhfp3lHujDFP_jZZ0HKD0lCG&s=v0z7khR7L321sfFdwhsHH9QW7xSdGjzfN5hH-EENwXQ&e= ).

Deadline for application is 15th of May, 2022.

Best wishes,
Mathieu

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Scientist Cryo-Electron Microscopy (100%)

The company
Founded in 2015, leadXpro AG is a rapidly growing biotech company focusing on solving structures of membrane protein drug targets (e.g. GPCRs, ion-channels and transporters) for the discovery and optimization of next-generation medicines. Based on a unique platform for membrane protein expression, purification and engineering, and preferential access to synchrotron and free electron laser (SLS/SwissFEL) beamlines for X-ray analysis and cryo-EM facilities, leadXpro characterizes the interaction of small molecules and biotherapeutics with drug targets in time to impact the discovery of novel therapeutics. This position at leadXpro AG is an excellent opportunity to join a young and exciting company engaged in cutting-edge applied research. leadXpro AG is located at PARK INNOVAARE, 5234 Villigen, Switzerland. For more information, please visit: https://urldefense.proofpoint.com/v2/url?u=http-3A__leadxpro.com&d=DwIF-g&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=g4z6bk6Ef4Ho7LRP9AbFGUliRFCScyYGBGgeRKRrDhfp3lHujDFP_jZZ0HKD0lCG&s=ORPElIJShPxrls3PyGO7kH2e2WQctquzHCbShz6CAc4&e= 

The position
leadXpro is seeking a highly motivated, creative, bench-oriented scientist who will be part of an interdisciplinary and international team working on leadXpro’s projects. Within the EM Team, the applicant will work on membrane protein structure determination projects using cryo-EM as primary method. Furthermore, you will further develop electron microscopy methods, especially with respect of sample vitrification and evaluation using emerging new technologies and contribute to the elucidation of membrane protein-ligand cryo-EM structures.

Key tasks and responsibilities


  *   Establish protocols for membrane protein vitrification using conventional and emerging technologies.
  *   Perform membrane protein sample vitrification optimization making use of tight interaction with membrane protein purification experts and own expertise in protein purification and formulation technologies.
  *   Cryo-EM grid quality inspection, for assessment of optimal ice quality and particle distribution using our in-house screening electron microscope.
  *   Collect and determine structures to investigate apo and potential drug ligand molecule interaction in high resolution cryo-EM structures.
  *   Contribute to the further development of the EM capabilities of leadXpro by keeping up to date with the new and emerging scientific innovations.
  *   Analyse, report and present data to project teams, clients or supervisors in an organized and dynamic way, enabling efficient project decision making.
  *   As project leader, be responsible and have the scientific merits to coordinate, organize as well as perform designated projects.
  *   Direct work interaction and collaboration with a multi-disciplinary team of scientists.


Key qualifications and requirements


  *   PhD in a relevant subject area such as protein biochemistry and structural biology is mandatory.
  *   Hands-on experience in biochemistry and cryo-electron microscopy (protein purification, sample vitrification, sample screening and electron microscope operation) is mandatory.
  *   Minimum 3 years’ work experience in cryo-EM and post-doc experience is preferred.
  *   Proficiency with cryo-EM software packages (CryoSPARC, RELION, EMAN2, Coot, Phenix, etc…) is highly recommended.

  *   Hands-on experience on membrane protein biochemistry is an asset.
  *   Knowledge on membrane protein formulation optimization (nanodiscs, amphipols, etc…) and experience with various vitrification systems is an advantage.
  *   Previous working experience in an industrial or biotech setting is considered a plus.
  *   Proven ability to work in a collaborative environment, coordinate complex and time-sensitive experiments with multiple partners (colleagues, facilities, clients, etc..).
  *   Excellent communication and presentation skills as well as fluency in English are essential.

How to apply

If you are interested to join the team, please send your complete application (compelling cover letter, most recent CV, relevant certificates) in English with the keyword “Scientist Cryo-EM (100%)” in the subject line to: info at leadXpro.com<mailto:info at leadXpro.com>

Applications will be evaluated continuously with a final deadline on the 15th of May, 2022.

--
Mathieu Botte
Principal Scientist, Head of Electron-Microscopy
leadXpro AG
PARK innovAARE
5234 Villigen, Switzerland

Phone: +33 6 50 35 92 35
email:mathieu.botte at leadxpro.com<mailto:mathieu.botte at leadxpro.com>
https://urldefense.proofpoint.com/v2/url?u=http-3A__www.leadxpro.com&d=DwIF-g&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=g4z6bk6Ef4Ho7LRP9AbFGUliRFCScyYGBGgeRKRrDhfp3lHujDFP_jZZ0HKD0lCG&s=fPuatlG8-JOVWvFpxkPjFBq6vRbNbiutBU_rCb0LFUk&e= 

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