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<p class="MsoNormal"><span lang="EN-US">Dear all,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">leadXpro is a biotech company located on the Paul Scherrer Institute (PSI) campus in Villigen, Switzerland. The company is specialized in solving structures of membrane protein drug targets for drug discovery.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">We have an open position for a scientist to work in the EM team. The job description can be found below, on the leadXpro website (<a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__leadxpro.com_scientist-2Dcryo-2Delectron-2Dmicroscopy-2D100_&d=DwMF-g&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=g4z6bk6Ef4Ho7LRP9AbFGUliRFCScyYGBGgeRKRrDhfp3lHujDFP_jZZ0HKD0lCG&s=GTavSlfYn8CA4Rq3okh_-482Z-VHZMqN43xx-K6NSPI&e=">https://leadxpro.com/scientist-cryo-electron-microscopy-100/</a>)
and on LinkedIn (</span><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.linkedin.com_jobs_view_3043291555&d=DwMF-g&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=g4z6bk6Ef4Ho7LRP9AbFGUliRFCScyYGBGgeRKRrDhfp3lHujDFP_jZZ0HKD0lCG&s=v0z7khR7L321sfFdwhsHH9QW7xSdGjzfN5hH-EENwXQ&e=" title="https://www.linkedin.com/jobs/view/3043291555"><span style="font-size:12.0pt">https://www.linkedin.com/jobs/view/3043291555</span></a><span lang="EN-US">).<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Deadline for application is 15<sup>th</sup> of May, 2022.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Best wishes,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Mathieu<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">------<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-right:3.75pt;text-align:center">
<b><span style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">Scientist Cryo-Electron Microscopy (100%)<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="margin-right:3.75pt;text-align:center">
<b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE"><o:p> </o:p></span></b></p>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">The company<o:p></o:p></span></b></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB">Founded in 2015, leadXpro AG is a rapidly growing biotech company focusing on solving structures of membrane
protein drug targets (e.g. GPCRs, ion-channels and transporters) for the discovery and optimization of next-generation medicines. Based on a unique platform for membrane protein expression, purification and engineering, and preferential access to synchrotron
and free electron laser (SLS/SwissFEL) beamlines for X-ray analysis and cryo-EM facilities, leadXpro characterizes the interaction of small molecules and biotherapeutics with drug targets in time to impact the discovery of novel therapeutics. This position at leadXpro
AG is an excellent opportunity to join a young and exciting company engaged in cutting-edge applied research. leadXpro AG is located at PARK INNOVAARE, 5234 Villigen, Switzerland. For more information, please visit: </span><a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__leadxpro.com&d=DwMF-g&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=g4z6bk6Ef4Ho7LRP9AbFGUliRFCScyYGBGgeRKRrDhfp3lHujDFP_jZZ0HKD0lCG&s=ORPElIJShPxrls3PyGO7kH2e2WQctquzHCbShz6CAc4&e="><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#0563C1;mso-fareast-language:EN-GB">http://leadxpro.com</span></a><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB"> <o:p></o:p></span></p>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">The position</span></b><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">leadXpro is seeking a highly motivated, creative, bench-oriented scientist
</span><span lang="EN-GB" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">who will
</span><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">be</span><span lang="EN-GB" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE"> part of an interdisciplinary and
international team </span><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">working on leadXpro’s projects.</span><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">
</span><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">Within the EM Team, the applicant will work on membrane protein structure determination projects using cryo-EM as primary method. Furthermore, you will
further develop electron microscopy methods, especially with respect of sample vitrification and evaluation using emerging new technologies and contribute to the elucidation of membrane protein-ligand cryo-EM structures.</span><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">Key tasks and responsibilities<o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE"><o:p> </o:p></span></p>
<ul style="margin-top:0cm" type="disc">
<li class="MsoListParagraphCxSpFirst" style="margin-right:3.75pt;margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:115%;mso-list:l1 level1 lfo1">
<span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;color:black;background:white">Establish protocols for membrane protein vitrification using conventional and emerging technologies.</span><span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;mso-fareast-language:DE"><o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-right:3.75pt;margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:115%;mso-list:l1 level1 lfo1">
<span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;color:black;background:white">Perform membrane protein sample vitrification optimization making use of tight interaction with membrane protein purification experts and
own expertise in protein purification and formulation technologies.</span><span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;mso-fareast-language:DE"><o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-right:3.75pt;margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:115%;mso-list:l1 level1 lfo1">
<span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;color:black;background:white">Cryo-EM grid quality inspection, for assessment of optimal ice quality and particle distribution using our in-house screening electron microscope.</span><span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;mso-fareast-language:DE"><o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-right:3.75pt;margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:115%;mso-list:l1 level1 lfo1">
<span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;color:black;background:white">Collect and determine structures to investigate apo and potential drug ligand molecule interaction in high resolution cryo-EM structures.</span><span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;mso-fareast-language:DE"><o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-right:3.75pt;margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:115%;mso-list:l1 level1 lfo1">
<span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;color:black;background:white">Contribute to the further development of the EM capabilities of leadXpro by keeping up to date with the new and emerging scientific innovations.</span><span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;mso-fareast-language:DE"><o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-right:3.75pt;margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:115%;mso-list:l1 level1 lfo1">
<span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;mso-fareast-language:DE">Analyse, report and present data to project teams, clients or supervisors in an organized and dynamic way, enabling efficient project decision
making.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-right:3.75pt;margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:115%;mso-list:l1 level1 lfo1">
<span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;mso-fareast-language:DE">As project leader, be responsible and have the scientific merits to coordinate, organize as well as perform designated projects.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-right:3.75pt;margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:115%;mso-list:l1 level1 lfo1">
<span lang="EN-GB" style="font-size:10.0pt;line-height:115%;font-family:"Arial",sans-serif;mso-fareast-language:DE">Direct work interaction and collaboration with a multi-disciplinary team of scientists.<o:p></o:p></span></li></ul>
<p class="MsoListParagraphCxSpLast" style="margin-right:3.75pt;mso-add-space:auto">
<span lang="EN-GB" style="font-size:10.0pt;line-height:120%;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-right:3.75pt"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">Key qualifications and requirements<o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-right:3.75pt"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE"><o:p> </o:p></span></b></p>
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<li class="MsoListParagraphCxSpFirst" style="color:black;margin-left:0cm;mso-add-space:auto;mso-list:l0 level1 lfo2">
<span lang="EN-GB" style="font-size:10.0pt;line-height:120%;font-family:"Arial",sans-serif;mso-fareast-language:DE">PhD in a relevant subject area such as protein biochemistry and structural biology is mandatory.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:0cm;mso-add-space:auto;mso-list:l0 level1 lfo2">
<span lang="EN-GB" style="font-size:10.0pt;line-height:120%;font-family:"Arial",sans-serif;mso-fareast-language:DE">Hands-on experience in biochemistry and cryo-electron microscopy (protein purification, sample vitrification, sample screening and electron microscope
operation) is mandatory.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:0cm;mso-add-space:auto;mso-list:l0 level1 lfo2">
<span lang="EN-GB" style="font-size:10.0pt;line-height:120%;font-family:"Arial",sans-serif;mso-fareast-language:DE">Minimum 3 years’ work experience in cryo-EM and post-doc experience is preferred.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:0cm;mso-add-space:auto;mso-list:l0 level1 lfo2">
<span lang="EN-GB" style="font-size:10.0pt;line-height:120%;font-family:"Arial",sans-serif;mso-fareast-language:DE">Proficiency with cryo-EM software packages (CryoSPARC, RELION, EMAN2, Coot, Phenix, etc…) is highly recommended.<o:p></o:p></span></li></ul>
<ul style="margin-top:0cm" type="disc">
<li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:0cm;mso-add-space:auto;mso-list:l2 level1 lfo3">
<span lang="EN-GB" style="font-size:10.0pt;line-height:120%;font-family:"Arial",sans-serif;mso-fareast-language:DE">Hands-on experience on membrane protein biochemistry is an asset.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:0cm;mso-add-space:auto;mso-list:l2 level1 lfo3">
<span lang="EN-GB" style="font-size:10.0pt;line-height:120%;font-family:"Arial",sans-serif;mso-fareast-language:DE">Knowledge on membrane protein formulation optimization (nanodiscs, amphipols, etc…) and experience with various vitrification systems is an advantage.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:0cm;mso-add-space:auto;mso-list:l2 level1 lfo3">
<span lang="EN-GB" style="font-size:10.0pt;line-height:120%;font-family:"Arial",sans-serif;mso-fareast-language:DE">Previous working experience in an industrial or biotech setting is considered a plus.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:0cm;mso-add-space:auto;mso-list:l2 level1 lfo3">
<span lang="EN-GB" style="font-size:10.0pt;line-height:120%;font-family:"Arial",sans-serif;mso-fareast-language:DE">Proven ability to work in a collaborative environment, coordinate complex and time-sensitive experiments with multiple partners (colleagues,
facilities, clients, etc..).<o:p></o:p></span></li><li class="MsoListParagraphCxSpLast" style="color:black;margin-left:0cm;mso-add-space:auto;mso-list:l2 level1 lfo3">
<span lang="EN-GB" style="font-size:10.0pt;line-height:120%;font-family:"Arial",sans-serif;mso-fareast-language:DE">Excellent communication and presentation skills as well as fluency in English are essential.
<o:p></o:p></span></li></ul>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE"><o:p> </o:p></span></b></p>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">How to apply</span></b><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black;mso-fareast-language:DE">If you are interested to join the team, please send your complete application (compelling cover
letter, most recent CV, relevant certificates) in English with the keyword “<b>Scientist Cryo-EM (100%)</b>” in the subject line to:
</span><a href="mailto:info@leadXpro.com"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;mso-fareast-language:DE">info@leadXpro.com</span></a><span class="MsoHyperlink"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><b><span style="color:red"><o:p> </o:p></span></b></p>
<p class="MsoNormal" style="margin-right:3.75pt;text-align:justify"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:red;mso-fareast-language:DE">Applications will be evaluated continuously with a final deadline on the 15<sup>th</sup> of
May, 2022. <o:p></o:p></span></b></p>
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<p class="MsoNormal"><span style="mso-fareast-language:EN-GB">-- <o:p></o:p></span></p>
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<p class="MsoNormal"><span lang="EN-US" style="color:black;mso-fareast-language:EN-GB">Mathieu Botte</span><span style="font-size:12.0pt;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="color:black;mso-fareast-language:EN-GB">Principal Scientist, Head of Electron-Microscopy</span><span style="font-size:12.0pt;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="color:black;mso-fareast-language:EN-GB">leadXpro AG</span><span style="font-size:12.0pt;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE" style="color:black;mso-fareast-language:EN-GB">PARK innovAARE</span><span style="font-size:12.0pt;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE" style="color:black;mso-fareast-language:EN-GB">5234 Villigen, Switzerland</span><span style="font-size:12.0pt;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE" style="color:black;mso-fareast-language:EN-GB"> </span><span style="font-size:12.0pt;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH" style="color:black;mso-fareast-language:EN-GB">Phone: +33 6 50 35 92 35</span><span style="font-size:12.0pt;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#2D4F8C;mso-fareast-language:EN-GB">email:</span><span lang="EN-US" style="color:#2D4F8C;mso-fareast-language:EN-GB"><a href="mailto:mathieu.botte@leadxpro.com"><span lang="EN-GB" style="color:#0563C1"><span lang="EN-GB">mathieu.botte@leadxpro.com</span></span></a></span><span style="font-size:12.0pt;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE" style="color:#2D4F8C;mso-fareast-language:EN-GB"><a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__www.leadxpro.com&d=DwMF-g&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=g4z6bk6Ef4Ho7LRP9AbFGUliRFCScyYGBGgeRKRrDhfp3lHujDFP_jZZ0HKD0lCG&s=fPuatlG8-JOVWvFpxkPjFBq6vRbNbiutBU_rCb0LFUk&e=" title="http://www.leadxpro.com"><span lang="EN-GB" style="color:#00006A"><span lang="EN-GB">http://www.leadxpro.com</span></span></a></span><span style="font-size:12.0pt;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:black;mso-fareast-language:EN-GB"> </span><span style="font-size:12.0pt;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH" style="color:black;mso-fareast-language:EN-GB"><img border="0" width="158" height="31" style="width:1.6458in;height:.3229in" id="Picture_x0020_1" src="cid:image001.png@01D85E2C.ED314230" alt="signature_1571250491"></span><span style="font-size:12.0pt;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
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