[3dem] Post-doctoral Position in CryoEM of Membrane Proteins in Sunny Singapore

[Yong Zi Tan]

The Tan lab in sunny Singapore is looking for a post-doctoral candidate who will work with Assistant Professor Tan Yong Zi on biochemistry and structural biology under a project entitled Understanding the Structure and Function of Mammalian Membrane Proteins Involved in Human Diseases.

While membrane proteins only make up around 20% of the proteome, they constitute around 60% of drug targets. However, high resolution structural information is severely lacking for them, with only about 2% of the structures deposited in the public protein database (PDB) being annotated as membrane proteins. The Tan lab (https://urldefense.proofpoint.com/v2/url?u=http-3A__www.tyzlab.com&d=DwIFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=4kMnwPj1WzTWt2XydZ5ABn_nl0tHiuYvFpM6ObBIyLa-QKnyJLdbXURp12vefusC&s=vUtsxFvsVFiZVXl9Ql8pgjt1wFQQzW1X1g6ofkYJ1Gs&e= <https://urldefense.proofpoint.com/v2/url?u=http-3A__www.tyzlab.com&d=DwIFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=4kMnwPj1WzTWt2XydZ5ABn_nl0tHiuYvFpM6ObBIyLa-QKnyJLdbXURp12vefusC&s=vUtsxFvsVFiZVXl9Ql8pgjt1wFQQzW1X1g6ofkYJ1Gs&e= >) strives to fill in this gap by targeting membrane proteins involved in human diseases such as cancer and diabetes. Our forte is using state-of-the-art single-particle cryogenic electron microscopy (cryo-EM) to obtain high-resolution atomic structures of these membrane proteins. We also actively work on methods development in cryo-EM that will help us answer our biological questions.

The Tan lab is generously funded by the NUS Presidential Young Professorship under the Department of Biological Sciences, NUS. We are a core member of the Centre for BioImaging Sciences' (CBIS), and have access to high-end cryo-EM microscopes, including a Titan Krios with K3 direct detector and energy filter.

Main Responsibilities

  *   Lead structural projects from protein expression, protein purification, activity assay, cryo-EM imaging, data processing to model building

Application Requirements

  *   Candidates must uphold values of scientific integrity, honesty, teamwork and pride in their work
  *   PhD in Biology/Biochemistry/Biophysics/Biotechnology or related field
  *   Experience with bacterial, insect and mammalian cell culture work is not essential but favoured
  *   Experience in protein purification experience is required
  *   Programming (such as Python) skills not essential but favoured
  *   Structural biology experience  not essential but favoured

Interested candidates please contact me at yztan at nus.edu.sg<mailto:yztan at nus.edu.sg>. Please provide a CV and names and contact of three referees.

Warmest Regards,
Yong Zi Tan
Assistant Professor
Department of Biological Sciences
National University of Singapore
https://urldefense.proofpoint.com/v2/url?u=http-3A__www.tyzlab.com&d=DwIFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=4kMnwPj1WzTWt2XydZ5ABn_nl0tHiuYvFpM6ObBIyLa-QKnyJLdbXURp12vefusC&s=vUtsxFvsVFiZVXl9Ql8pgjt1wFQQzW1X1g6ofkYJ1Gs&e= <https://urldefense.proofpoint.com/v2/url?u=http-3A__www.tyzlab.com&d=DwIFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=4kMnwPj1WzTWt2XydZ5ABn_nl0tHiuYvFpM6ObBIyLa-QKnyJLdbXURp12vefusC&s=vUtsxFvsVFiZVXl9Ql8pgjt1wFQQzW1X1g6ofkYJ1Gs&e= >

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