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<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif"">The Tan lab in sunny Singapore is looking for a post-doctoral candidate who will work with
<b>Assistant Professor Tan Yong Zi</b> on <b>biochemistry and structural biology </b>
under a project entitled <b>Understanding the Structure and Function of Mammalian Membrane Proteins Involved in Human Diseases.<o:p></o:p></b></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif"">While membrane proteins only make up around 20% of the proteome, they constitute around 60% of drug targets. However, high resolution structural information
is severely lacking for them, with only about 2% of the structures deposited in the public protein database (PDB) being annotated as membrane proteins. The Tan lab (<a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__www.tyzlab.com&d=DwMFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=4kMnwPj1WzTWt2XydZ5ABn_nl0tHiuYvFpM6ObBIyLa-QKnyJLdbXURp12vefusC&s=vUtsxFvsVFiZVXl9Ql8pgjt1wFQQzW1X1g6ofkYJ1Gs&e=">www.tyzlab.com</a>) strives to fill in this gap by targeting
membrane proteins involved in human diseases such as cancer and diabetes. Our forte is using state-of-the-art single-particle cryogenic electron microscopy (cryo-EM) to obtain high-resolution atomic structures of these membrane proteins. We also actively work
on methods development in cryo-EM that will help us answer our biological questions.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif"">The Tan lab is generously funded by the NUS Presidential Young Professorship under the Department of Biological Sciences, NUS. We are a core member of the Centre
for BioImaging Sciences' (CBIS), and have access to high-end cryo-EM microscopes, including a Titan Krios with K3 direct detector and energy filter.</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Main Responsibilities<o:p></o:p></span></p>
<ul style="margin-top:0cm" type="disc">
<li class="MsoNormal" style="mso-list:l2 level1 lfo3"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Lead structural projects from protein expression, protein purification, activity assay, cryo-EM imaging, data processing to model building<o:p></o:p></span></li></ul>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Application Requirements<o:p></o:p></span></p>
<ul style="margin-top:0cm" type="disc">
<li class="MsoNormal" style="mso-list:l1 level1 lfo6"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Candidates must uphold values of scientific integrity, honesty, teamwork and pride in their work<o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l1 level1 lfo6"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">PhD in Biology/Biochemistry/Biophysics/Biotechnology or related field<o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l1 level1 lfo6"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Experience with bacterial, insect and mammalian cell culture work is not essential but favoured<o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l1 level1 lfo6"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Experience in protein purification experience is required<o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l1 level1 lfo6"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Programming (such as Python) skills not essential but favoured<o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l1 level1 lfo6"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Structural biology experience not essential but favoured<o:p></o:p></span></li></ul>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Interested candidates please contact me at
<a href="mailto:yztan@nus.edu.sg">yztan@nus.edu.sg</a><span style="color:#1F497D">.</span> Please provide a CV and names and contact of three referees.</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Warmest Regards,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Yong Zi Tan<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Assistant Professor<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Department of Biological Sciences<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">National University of Singapore<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__www.tyzlab.com&d=DwMFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=4kMnwPj1WzTWt2XydZ5ABn_nl0tHiuYvFpM6ObBIyLa-QKnyJLdbXURp12vefusC&s=vUtsxFvsVFiZVXl9Ql8pgjt1wFQQzW1X1g6ofkYJ1Gs&e="><span style="color:windowtext">www.tyzlab.com</span></a><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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