[3dem] PhD position in cryo-ET at the University of Göttingen

[Ruben, Fernandez Busnadiego]

Dear all,


The following PhD position is open in my lab:


PhD student (m/f/d) for a project funded by the SFB 1190, "Compartmental Gates and Contact Sites in Cells"

The goal of the Fernandez-Busnadiego lab<https://urldefense.com/v3/__https://neuropathologie.umg.eu/forschung/arbeitsgruppen-labore/ag-fernandez-busnadiego/__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icSoB9Ty3w$ > is to unravel the structural basis of fundamental cellular mechanisms, as well as their alterations in human disease. To that end, we employ multidisciplinary approaches, pivoting on state-of-the art cryo-electron tomography (see e.g. Bäuerlein et al., Cell 2017<https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/28890085/__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icSofanVsw$ >; Guo et al., Cell 2018<https://urldefense.com/v3/__https://www.ncbi.nlm.nih.gov/pubmed/29398115__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icSF8rxK4Q$ >; Collado et al., Dev Cell 2019<https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/31743662/__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icQAvIaFOA$ >; Trinkaus et al., biorxiv 2020<https://urldefense.com/v3/__https://www.biorxiv.org/content/10.1101/2020.08.07.234138v1__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icR3G93HkQ$ >; click here<https://urldefense.com/v3/__https://www.ncbi.nlm.nih.gov/pubmed/?term=Fern**Andez-Busnadiego*20R*5BAuthor*5D&cauthor=true&cauthor_uid=29398115__;w6ElJSU!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icQ0Eh1Bdw$ > for a complete publication list).


The lab is integrated in the Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable cells" (MBExC<https://urldefense.com/v3/__https://mbexc.de/en/__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icQW6onm9A$ >). MBExC is an interdisciplinary, cross-faculty research center of the University of Göttingen and pursues a novel research approach with joint efforts in modern bioimaging, in particular photonics, molecular biosciences, neuroscience and cardiovascular research.  The goal of MBExC is to decipher disease relevant nanoscale functional units in neurons, sensory cells and cardiomyocytes with the long-term goal to develop innovative therapeutic strategies for disorders affecting the heart and the brain, or both.


The successful candidate will work on revealing the mechanisms by which membrane curvature contributes to lipid homeostasis in the cell (Collado et al., Dev Cell 2019<https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/31743662/__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icQAvIaFOA$ >). To that end, in vitro reconstitutions and in vivo mutagenesis in yeast will be combined with cryo-electron tomography imaging. The project will be integrated into the Collaborative Research Center SFB1190<https://urldefense.com/v3/__https://www.sfb1190.de/index.php?id=898__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icQmrHp9Jw$ >, a Göttingen-based consortium of groups studying membrane contact sites and compartmental gates from a highly multidisciplinary perspective.


We are looking for a highly motivated candidate with a M.Sc. in Biology or related disciplines and strong practical experience in biochemistry/cell biology. Practical experience in microscopy/structural biology is also highly desired.

Applications should include a motivation letter, CV and the contact details of at least two referees. They should be sent by email to ruben.fernandezbusnadiego at med.uni-goettingen.de<mailto:ruben.fernandezbusnadiego at med.uni-goettingen.de>.


Please also write to this address for informal inquiries.

Duration: 3 years
Salary scale: 65% of E13 (TV-L)


Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.

We look forward to receiving your application by 20.09.2020!



Prof. Dr. Ruben Fernandez-Busnadiego

University Medical Center Göttingen
Institute of Neuropathology
Justus-von-Liebig-Weg 11
37077 Göttingen
Germany

ruben.fernandezbusnadiego at med.uni-goettingen.de

https://urldefense.com/v3/__https://neuropathologie.umg.eu/forschung/arbeitsgruppen-labore/ag-fernandez-busnadiego/__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icSoB9Ty3w$ <https://urldefense.com/v3/__https://mail.biochem.mpg.de/OWA/redir.aspx?SURL=yV5A7zQhV8kCouGWmKl8x-C2WdM2-R_SWyQ2f9_HtNWwm0ZK7uTSCGgAdAB0AHAAOgAvAC8AdwB3AHcALgBiAGkAbwBjAGgAZQBtAC4AbQBwAGcALgBkAGUALwA0ADgANQA3ADgANgAwAC8AMAA0AF8AbgBlAHUAcgBvAF8AZABpAHMAZQBhAHMAZQA.&URL=http*3a*2f*2fwww.biochem.mpg.de*2f4857860*2f04_neuro_disease__;JSUlJSU!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icTUwqDFZQ$ >


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