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Dear all,

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<p>The following PhD position is open in my lab:</p>

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<h1 class="u-txt-center">PhD student (m/f/d) for a project funded by the SFB 1190, "Compartmental Gates and Contact Sites in Cells"</h1>

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<p><strong>The goal of the <a href="https://urldefense.com/v3/__https://neuropathologie.umg.eu/forschung/arbeitsgruppen-labore/ag-fernandez-busnadiego/__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icSoB9Ty3w$" class="OWAAutoLink">

Fernandez-Busnadiego lab</a> is to unravel the structural basis of fundamental cellular mechanisms, as well as their alterations in human disease</strong>. To that end, we employ multidisciplinary approaches, pivoting on state-of-the art

<strong>cryo-electron tomography</strong> (see e.g. <a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/28890085/__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icSofanVsw$" class="OWAAutoLink">

Bäuerlein et al., Cell 2017</a>; <span style="font-size:11.0pt; line-height:107%; font-family:"Calibri",sans-serif" lang="DE">

<a href="https://urldefense.com/v3/__https://www.ncbi.nlm.nih.gov/pubmed/29398115__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icSF8rxK4Q$"><span style="" lang="EN-US">Guo et al., Cell 2018</span></a></span><span style="font-size:11.0pt; line-height:107%; font-family:"Calibri",sans-serif">;

</span><span style="font-size:11.0pt; line-height:107%; font-family:"Calibri",sans-serif" lang="DE"><a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/31743662/__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icQAvIaFOA$"><span style="" lang="EN-US">Collado et al., Dev Cell 2019</span></a></span><span style="font-size:11.0pt; line-height:107%; font-family:"Calibri",sans-serif">;

</span><span style="font-size:11.0pt; line-height:107%; font-family:"Calibri",sans-serif" lang="DE"><a href="https://urldefense.com/v3/__https://www.biorxiv.org/content/10.1101/2020.08.07.234138v1__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icR3G93HkQ$"><span style="" lang="EN-US">Trinkaus et al., biorxiv 2020</span></a></span><span style="font-size:11.0pt; line-height:107%; font-family:"Calibri",sans-serif">;

 click </span><span style="font-size:11.0pt; line-height:107%; font-family:"Calibri",sans-serif" lang="DE"><a href="https://urldefense.com/v3/__https://www.ncbi.nlm.nih.gov/pubmed/?term=Fern**Andez-Busnadiego*20R*5BAuthor*5D&cauthor=true&cauthor_uid=29398115__;w6ElJSU!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icQ0Eh1Bdw$"><span style="" lang="EN-US">here</span></a></span><span style="font-size:11.0pt; line-height:107%; font-family:"Calibri",sans-serif">

 for a complete publication list</span>).</p>

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<p><strong>The lab is integrated in the Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable cells" (<span style="font-size:11.0pt;line-height:

107%;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;

mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:

minor-latin;mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi;

mso-ansi-language:DE;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="DE"><a href="https://urldefense.com/v3/__https://mbexc.de/en/__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icQW6onm9A$"><b style="mso-bidi-font-weight:normal"><span style="mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin;

mso-ansi-language:EN-US" lang="EN-US">MBExC</a>).

</strong>MBExC is an interdisciplinary, cross-faculty research center of the University of Göttingen and pursues a novel research approach with joint efforts in modern bioimaging, in particular photonics, molecular biosciences, neuroscience and cardiovascular

 research.  The goal of MBExC is to decipher disease relevant nanoscale functional units in neurons, sensory cells and cardiomyocytes with the long-term goal to develop innovative therapeutic strategies for disorders affecting the heart and the brain, or both.</p>

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<p><strong>The successful candidate</strong> will work on revealing the mechanisms by which membrane curvature contributes to lipid homeostasis in the cell (<span style="font-size:11.0pt; line-height:107%; font-family:"Calibri",sans-serif"></span><span style="font-size:11.0pt; line-height:107%; font-family:"Calibri",sans-serif" lang="DE"><a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/31743662/__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icQAvIaFOA$"><span style="" lang="EN-US">Collado

 et al., Dev Cell 2019</span></a></span><span style="font-size:11.0pt; line-height:107%; font-family:"Calibri",sans-serif"></span>). To that end,

<i>in vitro </i>reconstitutions and <i>in vivo</i> mutagenesis in yeast will be combined with cryo-electron tomography imaging. The project will be integrated into the

<strong>Collaborative Research Center </strong><a href="https://urldefense.com/v3/__https://www.sfb1190.de/index.php?id=898__;!!Mih3wA!StpflNRX780dWdSfVEpM_D3exI-tXv1ruK93FUH_5behwuxKj1GGpE67icQmrHp9Jw$" class="OWAAutoLink"><strong>SFB1190</strong></a>, a Göttingen-based consortium of groups studying membrane contact sites and compartmental gates from a highly multidisciplinary

 perspective.</p>

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<p><strong>We are looking for</strong> a highly motivated candidate with a M.Sc. in Biology or related disciplines and strong practical experience in biochemistry/cell biology. Practical experience in microscopy/structural biology is also highly desired.</p>

<p>Applications should include a <strong>motivation letter</strong>, <strong>CV </strong>

and the <strong>contact details of at least two referees</strong>. They should be sent by

<strong>email</strong> to<a href="mailto:ruben.fernandezbusnadiego@med.uni-goettingen.de"> ruben.fernandezbusnadiego@med.uni-goettingen.de</a>.</p>

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<p>Please also write to this address for informal inquiries.</p>

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<div>Duration: 3 years<br>

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<div>Salary scale: 65% of E13 (TV-L) </div>

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<div>Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.

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We look forward to receiving your application by 20.09.2020!

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<div style="margin:0"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt">Prof. Dr. Ruben Fernandez-Busnadiego</span></font></div>

</span></span></font>

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<div style="margin:0"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt">University Medical Center<font size="2" face="Tahoma"><span style="font-size:10pt"><span lang="en-US"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt">

 Göttingen </span></font></span></span></font></span></font></div>

<div style="margin:0"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt">Institute of Neuropathology<br>

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<div style="margin:0"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt">37077 Göttingen</span></font></div>

<div style="margin:0"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt">Germany</span></font><font size="2" face="Tahoma"><span style="font-size:10pt">

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<div style="margin:0"><font size="2" face="Tahoma"><span style="font-size:10pt">ruben.fernandezbusnadiego@med.uni-goettingen.de

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