[3dem] ManifoldEM software package

Sindelar, Charles charles.sindelar at yale.edu
Thu Feb 28 07:40:11 PST 2019

Dear Ali, Abbas, Joachim, I think I speak for all of us here at Yale saying we enthusiastically welcome your new software package. It is vital that your efforts (and cryo-EM methods development in general) receive strong funding support from the NIH and elsewhere, and I wholeheartedly back your efforts to be funded!!

Yours, Chuck   

    Date: Wed, 27 Feb 2019 20:13:09 +0000
    From: Ali Dashti <adashti at uwm.edu>
    To: "3dem at ncmir.ucsd.edu" <3dem at ncmir.ucsd.edu>
    Subject: [3dem] ManifoldEM software package
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    Dear 3DEM community members,
    We have developed a new open source software package for the community. ManifoldEM applies our manifold-based approach for mapping energy landscapes and analysis of functionally relevant continuous conformational changes from single-particle data (Dashti et al. PNAS 2014<https://nam05.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.pnas.org%2Fcontent%2F111%2F49%2F17492.short&data=02%7C01%7Ccharles.sindelar%40yale.edu%7C53f91ad860e646616e4208d69d765d01%7Cdd8cbebb21394df8b4114e3e87abeb5c%7C0%7C0%7C636869529041868419&sdata=YjiXP3zTxwtjDfqLyCEbEHMo3A8JByCZztPaN6iihmc%3D&reserved=0>, Dashti et al. BioRXiv 2019<https://nam05.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biorxiv.org%2Fcontent%2F10.1101%2F291922v2.abstract&data=02%7C01%7Ccharles.sindelar%40yale.edu%7C53f91ad860e646616e4208d69d765d01%7Cdd8cbebb21394df8b4114e3e87abeb5c%7C0%7C0%7C636869529041868419&sdata=ddi0uVewugbVtUqOk4q8BwFsObj43W4NMz1e%2FQ%2BRysA%3D&reserved=0>). We wanted to reach out to you with the news and ask if such a software were publicly available, would you like to receive it, and be supported in its installation & use?
    We seek to secure grant funding for dissemination, workshop training, user support, software maintenance and further development. The statements of interest from the community are critical for the success of the application.
    Best Regards,
    Ali Dashti, Abbas Ourmazd and Joachim Frank

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