[3dem] Postdoctoral Position in Cryo-EM & Biochemistry at ICR, London

Sebastian Guettler Sebastian.Guettler at icr.ac.uk
Tue Feb 19 01:08:41 PST 2019

Dear All,

Please see below for details of a new Postdoctoral Fellow position in my team (available from April 2019).

Best wishes,

Postdoctoral Training Fellow: Cryo-Electron Microscopy & Biochemistry

The Institute of Cancer Research (ICR)
Location: London (Chelsea)
Division: Structural Biology and Cancer Biology
Team: Structural Biology of Cell Signalling (Dr Sebastian Guettler)
Closing date: 17 March 2019

Following a Wellcome Trust Investigator Award to Dr Sebastian Guettler, a Postdoctoral Training Fellow position is available from 01 April 2019 in the Structural Biology of Cell Signalling team in the Divisions of Structural and Cancer Biology. Work in the Guettler laboratory centres on the elucidation of signal transduction mechanisms relevant to the function of cancer cells, in particular the Wnt/beta-catenin network and telomere homeostasis and their control by poly(ADP-ribosyl)ation. Research by the team combines structural biology, both by X-ray crystallography and cryo-electron microscopy, biochemistry, biophysics and functional studies in mammalian cells. For a research overview, please visit sguettlerlab.org or icr.ac.uk.

We are looking for a highly motivated and creative candiate with a strong interest in the structural and mechanistic characterisation of large multi-protein complexes. Applicants must have a PhD in a biological or physical science, and experience in biochemistry and cryo-electron microscopy.

Research in the Division of Structural Biology is aimed at understanding the structural basis for the function and regulation of proteins and protein complexes implicated in cancer. Our research programmes are complemented by close collaborations with other groups elsewhere in the Institute, including groups from the Divisions of Cancer Biology and Cancer Therapeutics, and provide the mechanistic and structural framework for developing new therapeutics targeting cancer. The Division of Structural Biology is well equipped with state-of-the-art in-house X-ray equipment and robotics, computational infrastructure, an in-house electron microscopy facility (including a high-end 200 keV microscope equipped with a direct electron camera and Volta phase plate to be installed in 2019) and has direct access to a 300 keV Krios microscope, as part of the LonCEM consortium. Links with synchrotron radiation sources and the Electron Bio-Imaging Centre (eBIC) for cryo-electron microscopy are established.

For further details and to apply, please visit the ICR Careers portal:

Informal enquiries can be made to sebastian.guettler at icr.ac.uk. (Please note that formal applications must be submitted online.)

  Sebastian Guettler, PhD
  Team Leader
  The Institute of Cancer Research (ICR)
  Divisions of Structural and Cancer Biology
  237 Fulham Road
  London, SW3 6JB
  United Kingdom

  e-mail: sebastian.guettler at icr.ac.uk
  web: www.sguettlerlab.org  | www.icr.ac.uk

The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP.

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