[3dem] 7 days to apply. Postdoctoral Position at Imperial College London - Speck Lab

Speck, Christian chris.speck at imperial.ac.uk
Sun Sep 30 06:03:50 PDT 2018


dear all,



Application deadline Sunday October 7th.


a postdoctoral position is available at Imperial College London.



The Speck Lab works on the mechanism of eukaryotic chromosome replication. We are looking for a passionate researcher interested in investigating molecular machines.

The ideal candidate will have Structural Biology expertise. Cryo-EM experience would be an advantage, but is not an absolute requirement.

Research framework and support structure:
1.)    Excellent access to cryo-EM instruments: 1 Krios microscope equipped with K3 detector; multiple 200kV and 100kV microscopes for cryo-EM grid screening; supported by outstanding facility manager and senior investigator scientist.

2.)    The group consists of >10 members, 7 postdocs, 2 students, including senior biochemical research scientist and lab manager that support protein expression and purification.

3.)    The lab is fully equipped for biochemistry (2 AKTAs, multiple temperature controlled shakers), cryo-EM data processing (GPU cluster and storage array) and generously supported by the Wellcome Trust and multiple BBSRC grants.

4.)    Access to state-of-the-art facilities including Mass Spectrometry, Structural Biology and Bioinformatics.

5.)    The candidate will receive direct mentoring by the group head on grant applications, writing of manuscripts and project design.

Interested individuals are welcome to contact me directly for more information.

Best,
Christian
chris.speck at imperial.ac.uk<mailto:chris.speck at imperial.ac.uk>

here are a few links:

The BBSRC funded 3-year position:

https://www.imperial.ac.uk/jobs/description/MED00740/research-associate-cryo-electron-microscopy/

The group:

http://www.specklab.com/

Closing date: 07 October 2018


Selected papers:

Noguchi Y*, Yuan Z*, Bai L*, Schneider S, Zhao G, Stillman B#, Speck C#, Li H# (2017) Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging strand DNA extrusion model PNAS, Nov 7;114(45):E9529-E953

Riera A, Barbon M, Noguchi Y, Reuter LM, Schneider S, Speck C (2017) From structure to mechanism - understanding initiation of DNA replication Genes & Development, Jun 1;31(11):1073-108

Yuan Z*, Riera A*, Bai L*, Sun J*, Nandi S, Spanos C, Chen ZA, Barbon M, Rappsilber J#, Stillman B#, Speck C# and Li H# (2017) Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 Nature Structure & Molecular Biology, Mar;24(3):316-32

Chang F, Riera A, Evrin C, Sun J, Li H, Speck C*, Weinreich M* (2015) Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication eLife, Aug 25;4

Samel AS, Fernández-Cid A, Sun J, Riera A, Tognetti S, Herrera MC, Li H, Speck C (2014) A unique DNA entry gate for regulated loading of the eukaryotic replicative helicase onto DNA Genes & Development, Aug 1;28(15):1653-6

Sun J*, Fernandez-Cid A*, Riera A*, Tognetti S, Yuan Z, Stillman B#, Speck C#, Li H# (2014) Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function Genes & Development, Oct 15;28(20):2291-30

Sun J*, Evrin C*, Samel S, Fernández-Cid A, Riera A, Kawakami H, Stillman B#, Speck C#, Li H# Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA (2013) Nature Structure & Molecular Biology, August 5, (20), 944-951

Fernández-Cid A, Riera A, Tognetti S, Herrera MC, Samel S , Evrin C, Winkler C, Gardenal E,   Uhle S, Speck C. (2013) An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM2-7 double-hexamer formation  Molecular Cell, Volume 50, Issue 4, 577-588, 18 April

__________________________________________

Professor Christian Speck, PhD, FRSB
Chair in Genome Biochemistry & Molecular Biology
Wellcome Trust Investigator

Imperial College London
Faculty of Medicine
Institute of Clinical Sciences (CRB room 3006)
Hammersmith Hospital Campus
Du Cane Road
London W12 0NN

Tel: 0044 20 8383 3387
Mobile: 0044 796 181 5557
Skype ID: dna_rep

email: christian.speck at imperial.ac.uk<mailto:christian.speck at imperial.ac.uk>
website: www.specklab.com<http://www.specklab.com/>
Imperial College website: www.imperial.ac.uk/people/chris.speck<http://www.imperial.ac.uk/people/chris.speck>

[http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtvm050463.jpg]     [cid:image002.png at 01D33B79.8BEFDA70]


-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20180930/da7d9428/attachment-0001.html>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image001.jpg
Type: image/jpeg
Size: 19356 bytes
Desc: image001.jpg
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20180930/da7d9428/attachment-0001.jpg>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image002.png
Type: image/png
Size: 25478 bytes
Desc: image002.png
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20180930/da7d9428/attachment-0001.png>


More information about the 3dem mailing list