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<p><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black">dear all,<o:p></o:p></span></p>
<p><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:red">Application deadline Sunday October 7<sup>th</sup>.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p><span style="font-family:"Calibri",sans-serif;color:black">a postdoctoral position is available at
<b>Imperial College London</b>. <o:p></o:p></span></p>
<p><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p><span style="font-family:"Calibri",sans-serif;color:black">The <b>Speck Lab</b> works on the mechanism of eukaryotic chromosome replication. We are looking for a passionate researcher interested in investigating molecular machines.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">The ideal candidate will have Structural Biology expertise. Cryo-EM experience would be an advantage, but is not an absolute requirement.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><b><span style="font-family:"Calibri",sans-serif;color:black">Research framework and support structure: <o:p></o:p></span></b></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo2;background:white">
<![if !supportLists]><span style="font-family:"Calibri",sans-serif;color:black"><span style="mso-list:Ignore">1.)<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Calibri",sans-serif;color:black">Excellent access to cryo-EM instruments: <b>1 Krios</b> microscope equipped with K3 detector; multiple 200kV<b> </b>and 100kV<b>
</b>microscopes for cryo-EM grid screening; supported by outstanding facility manager and senior investigator scientist.<o:p></o:p></span></p>
<p style="margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo2;background:white">
<![if !supportLists]><span style="font-family:"Calibri",sans-serif;color:black"><span style="mso-list:Ignore">2.)<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Calibri",sans-serif;color:black">The group consists of >10 members, 7 postdocs, 2 students, including senior biochemical research scientist and lab manager that support protein expression and purification.
<o:p></o:p></span></p>
<p style="margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo2;background:white">
<![if !supportLists]><span style="font-family:"Calibri",sans-serif;color:black"><span style="mso-list:Ignore">3.)<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Calibri",sans-serif;color:black">The lab is fully equipped for biochemistry (2 AKTAs, multiple temperature controlled shakers), cryo-EM data processing (GPU cluster and storage array) and generously supported
by the Wellcome Trust and multiple BBSRC grants.<o:p></o:p></span></p>
<p style="margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo2;background:white">
<![if !supportLists]><span style="font-family:"Calibri",sans-serif;color:black"><span style="mso-list:Ignore">4.)<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Calibri",sans-serif;color:black">Access to state-of-the-art facilities including Mass Spectrometry, Structural Biology and Bioinformatics.<o:p></o:p></span></p>
<p style="margin-left:36.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo2;background:white">
<![if !supportLists]><span style="font-family:"Calibri",sans-serif;color:black"><span style="mso-list:Ignore">5.)<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Calibri",sans-serif;color:black">The candidate will receive direct mentoring by the group head on grant applications, writing of manuscripts and project design.
<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">Interested individuals are welcome to contact me directly for more information.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">Best,<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">Christian<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:#2402EE"><a href="mailto:chris.speck@imperial.ac.uk"><span style="color:#2402EE">chris.speck@imperial.ac.uk</span></a></span><span style="font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><b><span style="font-family:"Calibri",sans-serif;color:black">here are a few links:</span></b><span style="font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">The BBSRC funded 3-year position:<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><u><span style="font-family:"Calibri Light",sans-serif;color:blue"><a href="https://www.imperial.ac.uk/jobs/description/MED00740/research-associate-cryo-electron-microscopy/">https://www.imperial.ac.uk/jobs/description/MED00740/research-associate-cryo-electron-microscopy/</a></span></u><span style="font-family:"Calibri Light",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">The group:<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:#2402EE"><a href="http://www.specklab.com/" id="LPlnk272504"><span style="color:#2402EE">http://www.specklab.com/</span></a><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">Closing date: 07 October 2018<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><b><span style="font-family:"Calibri",sans-serif;color:black">Selected papers:</span></b><span style="font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">Noguchi Y*, Yuan Z*, Bai L*, Schneider S, Zhao G, Stillman B#, Speck C#, Li H# (2017) Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging
strand DNA extrusion model <b>PNAS</b>, Nov 7;114(45):E9529-E953<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">Riera A, Barbon M, Noguchi Y, Reuter LM, Schneider S, Speck C (2017) From structure to mechanism – understanding initiation of DNA replication
<b>Genes & Development</b>, Jun 1;31(11):1073-108<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">Yuan Z*, Riera A*, Bai L*, Sun J*, Nandi S, Spanos C, Chen ZA, Barbon M, Rappsilber J#, Stillman B#, Speck C# and Li H# (2017) Structural basis of MCM2-7
replicative helicase loading by ORC-Cdc6 and Cdt1 <b>Nature Structure & Molecular Biology</b>, Mar;24(3):316-32<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">Chang F, Riera A, Evrin C, Sun J, Li H, Speck C*, Weinreich M* (2015) Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA
replication <b>eLife</b>, Aug 25;4<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">Samel AS, Fernández-Cid A, Sun J, Riera A, Tognetti S, Herrera MC, Li H, Speck C (2014) A unique DNA entry gate for regulated loading of the eukaryotic
replicative helicase onto DNA <b>Genes & Development</b>, Aug 1;28(15):1653-6<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">Sun J*, Fernandez-Cid A*, Riera A*, Tognetti S, Yuan Z, Stillman B#, Speck C#, Li H# (2014) Structural and mechanistic insights into Mcm2-7 double-hexamer
assembly and function <b>Genes & Development</b>, Oct 15;28(20):2291-30<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">Sun J*, Evrin C*, Samel S, Fernández-Cid A, Riera A, Kawakami H, Stillman B#, Speck C#, Li H# Cryo-EM structure of a helicase loading intermediate containing
ORC-Cdc6-Cdt1-MCM2-7 bound to DNA (2013) <b>Nature Structure & Molecular Biology</b>, August 5, (20), 944–951<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black">Fernández-Cid A, Riera A, Tognetti S, Herrera MC, Samel S , Evrin C, Winkler C, Gardenal E, Uhle S, Speck C. (2013) An ORC/Cdc6/MCM2-7 complex is formed
in a multistep reaction to serve as a platform for MCM2-7 double-hexamer formation
<b>Molecular Cell</b>, Volume 50, Issue 4, 577-588, 18 April<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">__________________________________________</span></i><i><span style="font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE"><o:p></o:p></span></i></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">Professor Christian Speck, PhD, FRSB<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">Chair in Genome Biochemistry & Molecular Biology</span></i><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">Wellcome Trust Investigator<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE"><o:p> </o:p></span></i></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">Imperial College London<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">Faculty of Medicine<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">Institute of Clinical Sciences (CRB room 3006)<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">Hammersmith Hospital Campus<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">Du Cane Road<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">London W12 0NN<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">Tel: 0044 20 8383 3387
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">Mobile: 0044 796 181 5557<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">Skype ID: dna_rep<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">email:
</span></i><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><a href="mailto:christian.speck@imperial.ac.uk"><span style="color:blue;mso-fareast-language:DE">christian.speck@imperial.ac.uk</span></a></span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#1F497D;mso-fareast-language:DE">website:
</span></i><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><a href="http://www.specklab.com/"><i><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:blue;mso-fareast-language:DE">www.specklab.com</span></i></a></span><i><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#1F497D;mso-fareast-language:DE">
</span></i><i><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:red;mso-fareast-language:DE"><o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#1F497D;mso-fareast-language:DE">Imperial College website:</span></i><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE">
</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><a href="http://www.imperial.ac.uk/people/chris.speck"><i><span style="color:blue;mso-fareast-language:DE">www.imperial.ac.uk/people/chris.speck</span></i></a></span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D;mso-fareast-language:DE"><o:p> </o:p></span></p>
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