[3dem] Postdoctoral opportunities at the Zuckerman Institute, Columbia University, New York, USA

[Anthony Fitzpatrick]

Dear all,



The Fitzpatrick lab, a member of the Zuckerman Mind Brain Behaviour
Institute at Columbia University (https://zuckermaninstitute.columbia.edu/),
has openings for four postdoctoral scientists.

Situated in the heart of Manhattan, the Zuckerman Institute houses sixty
laboratories employing a broad range of interdisciplinary approaches to
transform our understanding of the mind and brain. In this highly
collaborative environment, labs work together to gain critical insights
into human health by exploring how the brain develops, performs, endures
and recovers from trauma or disease.



In our lab, we leverage the latest developments in cryo-electron microscopy
with complementary biophysical techniques (proteomics, light-microscopy,
microfluidics) to explore the molecular basis of neurodegeneration (e.g.
PNAS 110, 5468-5473 and Nature 547, 185-190). To this end, we determine the
structure and function of protein complexes, purified directly from
postmortem brain tissue, that are implicated in a range of
neurodegenerative diseases. Additionally, we will visualize the behavior of
these complexes within the cellular context using light-microscopy and
cryo-electron tomography.



Members of the lab will have access to a state-of-the-art suite of electron
microscopes:



   - FEI F20 with Gatan K2 Summit direct electron detector
   - FEI Polara F30 with Gatan K2 Summit direct electron detector
   - FEI Titan Krios microscope with Gatan BioQuantum energy filter and
   K2/K3 Summit direct electron detector (Columbia-owned)
   - FEI Titan Krios microscope with Gatan BioQuantum energy filter and
   K2/K3 Summit direct electron detector (New York Structural Biology Center)
   - FEI Helios 650 SEM/FIB (New York Structural Biology Center)

In addition, two FEI Talos Arctica 200 kV microscopes with Gatan BioQuantum
energy filters and K3 Summit direct electron detectors (housed separately
at the Zuckerman Institute and Columbia University Medical School) and
another Titan Krios microscope with Gatan BioQuantum energy filter and K3
Summit direct electron detector will be installed in early 2018.



We are looking for outstanding scientists who have a strong background in
biophysics, biochemistry or neuroscience, and are highly motivated to learn
single-particle cryo-EM. Prior experience with single-particle cryo-EM
or X-ray crystallography is considered an advantage, but is not essential.



If you’re interested in joining our lab, please send your CV with a brief
description of your current research, as well as 2-3 contacts for
references, to awf2130 at columbia.edu before the *18th of September, 2017*.



Columbia University is an Affirmative Action/Equal Opportunity employer.
Columbia values diversity among its students, staff, and faculty and
strongly welcomes applications from women, persons with disabilities,
protected veterans, and underrepresented minorities.



Very best wishes,



Anthony Fitzpatrick
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