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<p class="MsoNormal" style="background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:Arial">Dear
all, <span></span></span></p>

<p class="MsoNormal" style="background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:Arial"><span> </span></span></p>

<p class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial">The Fitzpatrick lab,
a member of the Zuckerman Mind Brain Behaviour Institute at Columbia
University (<a href="https://zuckermaninstitute.columbia.edu/" target="_blank">https://zuckermaninstitute.co<wbr>lumbia.edu/</a>),
has openings for four postdoctoral scientists.</span><span style="font-size:9.5pt;font-family:Arial"><br>
<br>
<span></span></span></p>

<p class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;color:rgb(38,50,56)">Situated in the heart of Manhattan, the
Zuckerman Institute houses sixty laboratories employing a broad range of
interdisciplinary approaches to transform our understanding of the mind and
brain. In this highly collaborative environment, labs work together to gain
critical insights into human health by exploring how the brain develops,
performs, endures and recovers from trauma or disease.</span><span style="font-size:9.5pt;font-family:Times"><span></span></span></p>

<p class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial"><span> </span></span></p>

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<span style="font-size:9.5pt;font-family:Arial">In our lab, we leverage the latest developments
in cryo-electron microscopy with complementary biophysical techniques
(proteomics, light-microscopy, microfluidics) to explore the molecular basis of
neurodegeneration (e.g. PNAS 110, 5468-5473 and Nature 547, 185-190). To this
end, we determine the structure and function of protein complexes, purified
directly from postmortem brain tissue, that are implicated in a range of
neurodegenerative diseases. </span><span style="font-size:9.5pt;font-family:Arial;color:rgb(38,50,56)">Additionally, we will
visualize the behavior of these complexes within the cellular context using
light-microscopy and cryo-electron tomography.</span> </p><p class="MsoNormal">   <br></p>

<p class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;color:rgb(38,50,56)">Members of the lab will have access to a
state-of-the-art suite of electron microscopes: <span></span></span></p><p class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;color:rgb(38,50,56)"><br></span></p>



<ul style="margin-top:0in" type="disc"><li><span style="font-size:9.5pt;font-family:Arial;color:rgb(38,50,56)">FEI F20 with </span><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial">Gatan
K2 Summit direct electron detector </span><br></li>
 <li class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;color:rgb(38,50,56)">FEI Polara F30 with </span><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial">Gatan K2 Summit direct electron detector </span><span style="font-size:10pt;font-family:Times"><span></span></span></li>
 <li class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial">FEI Titan Krios microscope </span><span style="font-size:9.5pt;font-family:Arial;color:rgb(38,50,56)">with Gatan BioQuantum energy filter and</span><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial"> K2/K3 Summit direct electron detector (Columbia-owned)<span></span></span></li>
 <li class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial">FEI Titan Krios microscope </span><span style="font-size:9.5pt;font-family:Arial;color:rgb(38,50,56)">with Gatan BioQuantum energy filte</span><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial">r and K2/K3 Summit direct electron detector (New York
     Structural Biology Center)<span></span></span></li>
 <li class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial">FEI Helios 650 SEM/FIB (New York Structural Biology
     Center)</span></li></ul>

<p class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;color:rgb(38,50,56)">In addition, two FEI Talos Arctica 200 kV
microscopes with Gatan BioQuantum energy filters and K3 Summit direct electron
detectors (housed separately at the Zuckerman Institute and Columbia University
Medical School) and another Titan </span><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial">Krios microscope </span><span style="font-size:9.5pt;font-family:Arial;color:rgb(38,50,56)">with
Gatan BioQuantum energy filte</span><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial">r
and K3 Summit direct electron detector will</span><span style="font-size:9.5pt;font-family:Arial;color:rgb(38,50,56)"> be
installed in early 2018.</span><span style="font-size:10pt;font-family:Times"><span></span></span></p>

<p class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial"><span> </span></span></p>

<p class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial">We are looking for
outstanding scientists who have a strong background in biophysics, biochemistry
or neuroscience, and are highly motivated to learn single-particle
cryo-EM. Prior experience with single-particle cryo-EM or X-ray
crystallography is considered an advantage, but is not essential.</span><span style="font-size:10pt;font-family:Times">
</span><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial"><span></span></span></p>

<p class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial"><span> </span></span></p>

<p class="MsoNormal"><span style="font-size:9.5pt;font-family:Arial;background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial">If you’re interested in
joining our lab, please send your CV with a brief description of your
current research, as well as 2-3 contacts for references, to <a href="mailto:awf2130@columbia.edu" target="_blank">awf2130@columbia.edu</a></span><span style="font-size:10pt;font-family:Times">
</span><span style="font-size:9.5pt;font-family:Arial">before the <b>18^th of September,
2017</b>.</span><span style="font-size:10pt;font-family:Times"><span></span></span></p>

<p class="MsoNormal" style="background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:Arial"><span> </span></span></p>

<p class="MsoNormal"><span style="font-size:9pt;font-family:Arial">Columbia University is an Affirmative
Action/Equal Opportunity employer. Columbia values diversity among its
students, staff, and faculty and strongly welcomes applications from women,
persons with disabilities, protected veterans, and underrepresented minorities.<span></span></span></p>

<p class="MsoNormal" style="background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:Arial"><span> </span></span></p>

<p class="MsoNormal" style="background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:Arial">Very
best wishes,<span></span></span></p>

<p class="MsoNormal" style="background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:Arial"><span> </span></span></p>

<p class="MsoNormal" style="background-image:initial;background-size:initial;background-origin:initial;background-clip:initial;background-position:initial;background-repeat:initial"><span style="font-size:9.5pt;font-family:Arial">Anthony
Fitzpatrick<span></span></span></p>

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