[3dem] Postdoc/Research Scientist in structural biology of large complexes

[Petr Leiman]

A Postdoctoral or Research Scientist position is available at the University of Texas Medical Branch in Galveston in the laboratory of Petr Leiman to study the function of phage tails, R-type pyocins and the type VI secretion by means of cryoEM, X-ray crystallography, modeling and molecular biology techniques. With recent advances in cryoEM, we are finally in the realm of all-atom description of these fascinating biological systems that resemble human-made syringes and springs complete with pistons, needles, spikes, etc.

We are looking for a person with a track record in cryoEM, but candidates with a strong training in crystallography or any other area of structural biology will be considered. Proven wetlab experience in working with protein complexes is an advantage. 

On July 1, 2016, the Leiman lab will join the Sealy Center for Structural Biology and Molecular Biophysics http://www.scsb.utmb.edu/ that provides access to X-ray, cryoEM, NMR and Solution biophysics facilities as well as training and experimental assistance. Of particular importance is a Jeol 2200FS instrument that is equipped with a DE-20 direct electron detector and which is installed in a bio-containment facility suitable for imaging BSL-3 pathogens. A scientifically simulating atmosphere of the Sealy Center is supported by 22 core and 15 associated faculty. The Sealy Center for Structural Biology is located on the UTMB Galveston campus and is a short drive to Houston. A mild subtropical climate and affordability make Galveston a great place to live.   

The salary is commensurate with experience and accomplishments. The funding is guaranteed for 4 years. 

To apply, please email a cover letter, CV, and contact information for three referees to petr.leiman at epfl.ch. Visa sponsorship is available for non-US nationals. 

Relevant publications: 
* Structure of the T4 baseplate and its function in triggering sheath contraction. Taylor NM, Prokhorov NS, Guerrero-Ferreira RC, Shneider MM, Browning C, Goldie KN, Stahlberg H, Leiman PG. Nature. 2016 May 18;533(7603):346-52. doi: 10.1038/nature17971.

* PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Shneider MM, Buth SA, Ho BT, Basler M, Mekalanos JJ, Leiman PG. Nature. 2013 Aug 15;500(7462):350-3. doi: 10.1038/nature12453.

* Phage pierces the host cell membrane with the iron-loaded spike. Browning C, Shneider MM, Bowman VD, Schwarzer D, Leiman PG. Structure. 2012 Feb 8;20(2):326-39. doi: 10.1016/j.str.2011.12.009.

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Petr Leiman
EPFL
BSP 415
CH-1015 Lausanne
Switzerland
Office: +41 21 69 30 441
Mobile: +41 79 538 7647
Fax: +41 21 69 30 422
http://lbbs.epfl.ch