[3DEM] Staff Scientist Position at NIH

[Jenny Hinshaw]

Staff Scientist Position Available
Laboratory of Cell Biochemistry and Biology
National Institute of Health, USA

A staff scientist position is available in the 
laboratory of Jenny Hinshaw at NIH.  The 
qualified candidate may participate in ongoing 
research projects of the Hinshaw laboratory 
and/or initiate independent research projects in 
closely related fields. The successful candidate 
should have a Ph.D. with postdoctoral experience 
in Cell and Structural biology involving cryo-EM 
and image processing. 

A major focus of our research is calculating 3 
dimensional structures of proteins involved in 
endocytosis and membrane remodeling events. We 
currently have solved the structure of a dynamin 
mutant in the constricted and non-constricted 
states to a resolution of 20 Å.  Dynamin is 
crucial for endocytosis, synaptic membrane 
recycling, membrane trafficking within the cell 
and more recently has been associated with 
filamentous actin.  Other dynamin family members 
are involved in mitochondria division and 
morphology (Drp1, Mgm1), anti-viral activity (Mx, 
hGBP1), and plant cell wall  formation and 
thylakoid membrane organization (Phragmoplastin, 
ADLs). To determine if a common mechanism exists 
among this unique set of proteins, we plan to 
calculate and compare the 3D structure of dynamin 
family members using cryo-electron microscopy, 
helical reconstruction  and single particle 
methods.  Another interest of the laboratory is 
to determine the 3-dimensional structure of the 
nuclear pore complex (NPC) in C. Elegans.  This 
project will entail developing a method of 
isolating NPCs from C. Elegans and comparing 
various NPC mutants using the C. Elegans 
well-developed genetic system.  The 3D structure 
of Xenopus NPC was previously solved by Drs. 
Hinshaw, Carragher and Milligan and will be used 
as a model system for developing the C. Elegans 
system. 


Contact:  Jenny E. Hinshaw

Laboratory of Cell Biochemistry and Biology
NIDDK, NIH
Building 8, Room 419
8 Center Dr MSC 0851
Bethesda, MD 20892, USA

phone: +1 301 594 0842
fax: +1 301 496 9431
e-mail: jennyh at helix.nih.gov

http://dynamin.niddk.nih.gov/
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