Large Structures Meeting-Asilomar-Aprill, 2002

David DeRosier derosier at brandeis.edu
Fri Sep 28 08:00:33 PDT 2001


The Biophysical Discussions
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Frontiers in Structural Cell Biology:

Determining the structures of large subcellular machines

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Meeting Dates: April 20-22, 2002.
 Meeting Site: Asilomar, California.  This is a spectacular site.  You can see it at http://www.asilomarcenter.com/.

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The biophysical discussions are set up so that the discussion time is greater than the times allotted for presentations, which will be available on the web prior to the meeting.  The format is unusual, but highly successful. 

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To apply send a letter of intent to discussions at biophysics.org by November 15, 2001. Space is limited.

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Organizing committee: Axel Brunger (Stanford University), David DeRosier (Brandeis University), Steve Harrison (Harvard University), and Eva Nogales (University of California at Berkeley).

The Program (Saturday, April 20, 9 am to Monday, April 22, 12 noon)

Session I.   The state of structural biology of large structures.

            Moderator Helen Saibil

              Richard Henderson

                        The power of electron cryomicroscopy.

              Joachim Frank

                        The Ribosome -- a molecular machine in motion

              Jamie Cate

                        Biochemical basis for x-ray crystallography of the ribosome

 Session II.   Extending x-ray crystallography to ever larger structures

            Moderator Keith Hodgson

              Andy Thompson

                        Can we routinely collect useful data from micro-crystals?

  Janos Hajdu

            Future X-ray sources (tentative)

              Randy Reed

                        The phase problem: does size matter?

 Session III.   New ways to obtain large complexes for structural studies

            Moderator Axel Brunger

            Don Wiley

                        Stabilizing multi-component biological complexes for structural studies by protein engineering, expression, and refolding - AND - avoiding artifacts

            TBA

                        Expression and co-expression of components (tentative title)

 Session IV.   What does the future hold for electron cryomicroscopy?

            Moderator Bob Glaeser

            Niko Grigorieff 

Single particles always fit the mold

            Ken Downing               

The hybrid approach to electron crystallography

            Wolfgang Baumeister

                        Electron Tomography: Towards visualizing macromolecular assemblies inside cells

            Ed Egelman

Polymorphism, can we detect it? Can we use it? Can we control it?  Examples from actin and nucleoprotein complexes.

 Session V.   Can hybrid methods provide credible atomic models?

            Moderator Eva Nogales

            Niels Volkmann

                        Atomic model of the cell: docking in a tomographic environment

            Willy Wriggers

Reconciling Shape with Structure: Morphometric Strategies for
Multi-Resolution Flexing

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