[3dem] [Announce] RELION 5 / nextPYP web interface — beta call, demo 12 Jun, workshop 8–15 Jun

[Lakshmi Narasimhan]

Dear 3DEM Community,

We are excited to share two updates from our group with the cryo-EM
community

*1. Beta testers wanted*

We have built a standalone web interface for *RELION 5* (single-particle
analysis) and *nextPYP* (tomography - which already ships with a web
interface of its own) that integrates with *Open OnDemand*. The aim is to
make these pipelines usable without command-line work, while keeping the
underlying Slurm scheduler and the RELION / nextPYP binaries unchanged.

Because GPU instances and hardware are in short supply and expensive, the
deployment is *CPU-focused*, using parallelization across many cores rather
than relying on GPU acceleration.

*What you can do on the platform*

Upload your own cryo-EM dataset and run the full pipeline through the web
interface - from raw movies through motion correction, CTF estimation,
particle picking, 2D/3D classification, refinement, and post-processing,
all the way to a *final 3D structure*. Single-particle (RELION 5) and
tomography
(nextPYP) workflows are both supported. Everything runs through the existing
Slurm scheduler in the background.

*What we are offering now*

Self-hosted deployment on your existing institutional cluster - we install
and configure the web interface in your environment (Open OnDemand
required), integrate it with your Slurm queues, and provide setup and
ongoing support during the beta. Your data stays in your storage; no upload
to a third-party.

*What is coming next*

We are also developing *PractiCloud*, a fully managed, standalone
environment of the same platform for users who do not have an institutional
cluster or who prefer not to host. PractiCloud will go live after the beta
testing - register your interest now, and we will notify you as soon as it
is ready.

*Who we are looking for*

Early adopters at academic and industry sites to evaluate the platform,
give us workflow feedback, and help shape the production release. *No fee
for academic institutions* during the beta (light support included). *Industry
and commercial organizations* can join for a nominal fee.

*Live demo — 13 June 2026, 09:30 EST*

For a first look at the platform, we will run a demonstration on *12* *June*
*2026* *at* *09:30* *EST*, held as part of our 7-day workshop. Use the
link below
for the workshop.


For more details: *https://urldefense.com/v3/__https://practi-cloud.com/__;!!Mih3wA!GgNvZBQriQIZzArZa1oei42iJLK98PVRzVo5ZPCeb8SQHWiIDXfVlKhuy98OzLMPLJA9Cl1bKq3_PYS2N3r1D9fCGYNVeA$  <https://urldefense.com/v3/__https://practi-cloud.com/__;!!Mih3wA!GgNvZBQriQIZzArZa1oei42iJLK98PVRzVo5ZPCeb8SQHWiIDXfVlKhuy98OzLMPLJA9Cl1bKq3_PYS2N3r1D9fCGYNVeA$ >*

If you would like to be considered, please fill in the form at:
https://urldefense.com/v3/__https://forms.gle/6GZBGTv5qwxXmNzq7__;!!Mih3wA!GgNvZBQriQIZzArZa1oei42iJLK98PVRzVo5ZPCeb8SQHWiIDXfVlKhuy98OzLMPLJA9Cl1bKq3_PYS2N3r1D9f3SaMwcg$ 


*2. **W**orkshop — Fundamentals of Structural Biology — 8–15 June 2026*

A 7-day online program, jointly organised by *BioNEST–BHU (InnoResTech
Foundation, Banaras Hindu University)* and *Biosyntiya Solutions*.

*Topics*

- Cryo-EM: single-particle analysis

- Sample preparation and vitrification

- Data collection

- Image processing and 3D reconstruction

- X-ray crystallography

- NMR

- Structure prediction

- Molecular docking and drug design

- Demo on *RELION* and *nextPYP* using the PractiCloud platform

*Details*

- Dates: 8–15 June 2026

- Time: 19:00 IST / 09:30 EST

- Format: online live sessions

- Certificate: e-certificate jointly issued by BioNEST–BHU and Biosyntiya
Solutions

- Seats are limited

- Registration and full programme: *https://urldefense.com/v3/__https://biosyntiya.com/cryoem-workshop/__;!!Mih3wA!GgNvZBQriQIZzArZa1oei42iJLK98PVRzVo5ZPCeb8SQHWiIDXfVlKhuy98OzLMPLJA9Cl1bKq3_PYS2N3r1D9fmXIcF0A$ 
<https://urldefense.com/v3/__https://biosyntiya.com/cryoem-workshop/__;!!Mih3wA!GgNvZBQriQIZzArZa1oei42iJLK98PVRzVo5ZPCeb8SQHWiIDXfVlKhuy98OzLMPLJA9Cl1bKq3_PYS2N3r1D9fmXIcF0A$ >*

Both initiatives are open to academic and industry participants worldwide.

We are happy to answer technical questions.


P.S. - On the hardware side, we have also launched a *low-cost
open-hardware platform for cryo-EM sample preparation - **Vitriflex*, an
affordable alternative to commercial hardware.

More information: *https://urldefense.com/v3/__https://sshexa.com/hexarobotics__;!!Mih3wA!GgNvZBQriQIZzArZa1oei42iJLK98PVRzVo5ZPCeb8SQHWiIDXfVlKhuy98OzLMPLJA9Cl1bKq3_PYS2N3r1D9fNUQ8ekQ$ 
<https://urldefense.com/v3/__https://sshexa.com/hexarobotics__;!!Mih3wA!GgNvZBQriQIZzArZa1oei42iJLK98PVRzVo5ZPCeb8SQHWiIDXfVlKhuy98OzLMPLJA9Cl1bKq3_PYS2N3r1D9fNUQ8ekQ$ >*


Best regards,
Lakshmi Narasimhan Y

PractiCloud
https://urldefense.com/v3/__https://practi-cloud.com/__;!!Mih3wA!GgNvZBQriQIZzArZa1oei42iJLK98PVRzVo5ZPCeb8SQHWiIDXfVlKhuy98OzLMPLJA9Cl1bKq3_PYS2N3r1D9fCGYNVeA$ 
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20260526/25d9a461/attachment-0001.html>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: Fundamentals_of_StructuralBiologyWorkshop.jpeg
Type: image/jpeg
Size: 394872 bytes
Desc: not available
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20260526/25d9a461/attachment-0001.jpeg>