[3dem] CAHRA Challenge deadline extension to June 13th

[Joel Greer - STFC UKRI]

Hi all,

A last-minute reminder to participate in the ongoing CAHRA heterogeneity analysis challenge<https://urldefense.com/v3/__http://heterogeneity.notion.site/challenge__;!!Mih3wA!DjTjx3_bsKi9TDKARpb3r791TmPz_Z1uJOe5K32_IEYz080buM05ogO_TyOXGFm10EQHRDgouWVZroJgz4ewU6UNMg$ >.

We are now accepting submissions until June 13, 2026 (before the GRC), and we have over $10k in prizes.

We’re very interested to see how experts and practitioners process the datasets. The goal is to reveal our community's best practices and methodologies for heterogeneity analysis.

The results of the challenge will be shared at the CAHRA review workshop<https://urldefense.com/v3/__https://heterogeneity.notion.site/workshop__;!!Mih3wA!DjTjx3_bsKi9TDKARpb3r791TmPz_Z1uJOe5K32_IEYz080buM05ogO_TyOXGFm10EQHRDgouWVZroJgz4cK3pfA6w$ > from September 16-18, hosted at the Rutherford Appleton Laboratory (RAL), Harwell in Oxfordshire, UK.

Best wishes,
Joel
on behalf of the CAHRA Challenge team

More details:
Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)
Benchmark methods for heterogeneous structure determination, for cryo-EM practitioners and method developers

  *   Website: heterogeneity.notion.site/challenge<https://urldefense.com/v3/__http://heterogeneity.notion.site/challenge__;!!Mih3wA!DjTjx3_bsKi9TDKARpb3r791TmPz_Z1uJOe5K32_IEYz080buM05ogO_TyOXGFm10EQHRDgouWVZroJgz4ewU6UNMg$ >
  *   3 datasets for modeling heterogeneity:
     *   Compositional Heterogeneity <https://urldefense.com/v3/__https://heterogeneity.notion.site/compositional-heterogeneity__;!!Mih3wA!DjTjx3_bsKi9TDKARpb3r791TmPz_Z1uJOe5K32_IEYz080buM05ogO_TyOXGFm10EQHRDgouWVZroJgz4e0UXxsoA$ > (1.6M particles, experimental): identify complexes from an unspecified mixture
     *   Conformational Heterogeneity <https://urldefense.com/v3/__https://heterogeneity.notion.site/conformational-heterogeneity__;!!Mih3wA!DjTjx3_bsKi9TDKARpb3r791TmPz_Z1uJOe5K32_IEYz080buM05ogO_TyOXGFm10EQHRDgouWVZroJgz4dnCmGisA$ > (1.75M particles, simulated): build an ensemble of atomic models of a protein conformational change
     *   Pose Entanglement <https://urldefense.com/v3/__https://heterogeneity.notion.site/pose-entanglement__;!!Mih3wA!DjTjx3_bsKi9TDKARpb3r791TmPz_Z1uJOe5K32_IEYz080buM05ogO_TyOXGFm10EQHRDgouWVZroJgz4dC6wQW5w$ > (30k particles, simulated): estimate particle class populations of a two-state complex with orientation bias
  *   More than $10,000 in prizes
  *   Review workshop in the UK, September 16-18, 2026
  *   Submissions accepted for any dataset until June 13, 2026

-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20260526/f0983df4/attachment.html>