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Hi all,<br>
<br>
A last-minute reminder to participate in the ongoing <a href="https://urldefense.com/v3/__http://heterogeneity.notion.site/challenge__;!!Mih3wA!DjTjx3_bsKi9TDKARpb3r791TmPz_Z1uJOe5K32_IEYz080buM05ogO_TyOXGFm10EQHRDgouWVZroJgz4ewU6UNMg$" target="_blank" id="OWA98d31b8d-33a0-782e-2f83-e2ca860483e0" class="OWAAutoLink" title="http://heterogeneity.notion.site/challenge" rel="noopener noreferrer" data-auth="NotApplicable" data-linkindex="0" data-ogsc="">
CAHRA heterogeneity analysis challenge</a>.<br>
<br>
We are now accepting submissions until <b>June 13, 2026 </b>(before the GRC), and we have over
<b>$10k in prizes</b>.<br>
<br>
We’re very interested to see how experts and practitioners process the datasets. The goal is to reveal our community's best practices and methodologies for heterogeneity analysis.<br>
<br>
The results of the challenge will be shared at the <a href="https://urldefense.com/v3/__https://heterogeneity.notion.site/workshop__;!!Mih3wA!DjTjx3_bsKi9TDKARpb3r791TmPz_Z1uJOe5K32_IEYz080buM05ogO_TyOXGFm10EQHRDgouWVZroJgz4cK3pfA6w$" target="_blank" id="OWA97362d12-6f28-e739-b51b-cf64f839c013" class="OWAAutoLink" title="https://heterogeneity.notion.site/workshop" rel="noopener noreferrer" data-auth="NotApplicable" data-linkindex="1" data-ogsc="">
CAHRA review workshop</a> from September 16-18, hosted at the Rutherford Appleton Laboratory (RAL), Harwell in Oxfordshire, UK.<br>
<br>
Best wishes,<br>
Joel</div>
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on behalf of the CAHRA Challenge team<br>
<br>
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<i>More details:</i></div>
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<b>Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)<br>
</b>Benchmark methods for heterogeneous structure determination, for cryo-EM practitioners and method developers</div>
<ul>
<li style="font-family: Aptos, "Aptos_EmbeddedFont", "Aptos_MSFontService", Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0); margin-left: 15px;">
<b>Website: </b><a href="https://urldefense.com/v3/__http://heterogeneity.notion.site/challenge__;!!Mih3wA!DjTjx3_bsKi9TDKARpb3r791TmPz_Z1uJOe5K32_IEYz080buM05ogO_TyOXGFm10EQHRDgouWVZroJgz4ewU6UNMg$" target="_blank" id="OWA4a3ca396-99ec-52b4-bb65-3a3b84d261af" class="OWAAutoLink" title="http://heterogeneity.notion.site/challenge" rel="noopener noreferrer" data-auth="NotApplicable" data-linkindex="2" data-ogsc=""><b>heterogeneity.notion.site/challenge</b></a></li><li style="font-family: Aptos, "Aptos_EmbeddedFont", "Aptos_MSFontService", Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0); margin-left: 15px;">
3 datasets for modeling heterogeneity:</li><ul>
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<a href="https://urldefense.com/v3/__https://heterogeneity.notion.site/compositional-heterogeneity__;!!Mih3wA!DjTjx3_bsKi9TDKARpb3r791TmPz_Z1uJOe5K32_IEYz080buM05ogO_TyOXGFm10EQHRDgouWVZroJgz4e0UXxsoA$" target="_blank" id="OWA120664c2-fa55-fd6e-43ca-d8a7a8362e36" class="OWAAutoLink" title="https://heterogeneity.notion.site/compositional-heterogeneity" rel="noopener noreferrer" data-auth="NotApplicable" data-linkindex="3" data-ogsc="">Compositional
Heterogeneity </a>(1.6M particles, experimental): identify complexes from an unspecified mixture</li><li style="font-family: Aptos, "Aptos_EmbeddedFont", "Aptos_MSFontService", Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0); margin-left: 15px;">
<a href="https://urldefense.com/v3/__https://heterogeneity.notion.site/conformational-heterogeneity__;!!Mih3wA!DjTjx3_bsKi9TDKARpb3r791TmPz_Z1uJOe5K32_IEYz080buM05ogO_TyOXGFm10EQHRDgouWVZroJgz4dnCmGisA$" target="_blank" id="OWAce3246e2-f919-6ef4-65bd-d435385c090d" class="OWAAutoLink" title="https://heterogeneity.notion.site/conformational-heterogeneity" rel="noopener noreferrer" data-auth="NotApplicable" data-linkindex="4" data-ogsc="">Conformational
Heterogeneity </a>(1.75M particles, simulated): build an ensemble of atomic models of a protein conformational change</li><li style="font-family: Aptos, "Aptos_EmbeddedFont", "Aptos_MSFontService", Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0); margin-left: 15px;">
<a href="https://urldefense.com/v3/__https://heterogeneity.notion.site/pose-entanglement__;!!Mih3wA!DjTjx3_bsKi9TDKARpb3r791TmPz_Z1uJOe5K32_IEYz080buM05ogO_TyOXGFm10EQHRDgouWVZroJgz4dC6wQW5w$" target="_blank" id="OWAcc55b8b6-9d32-df15-8128-dbd636428799" class="OWAAutoLink" title="https://heterogeneity.notion.site/pose-entanglement" rel="noopener noreferrer" data-auth="NotApplicable" data-linkindex="5" data-ogsc="">Pose
Entanglement </a>(30k particles, simulated): estimate particle class populations of a two-state complex with orientation bias</li></ul>
<li style="font-family: Aptos, "Aptos_EmbeddedFont", "Aptos_MSFontService", Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0); margin-left: 15px;">
More than $10,000 in prizes</li><li style="font-family: Aptos, "Aptos_EmbeddedFont", "Aptos_MSFontService", Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0); margin-left: 15px;">
Review workshop in the UK, September 16-18, 2026</li><li style="font-family: Aptos, "Aptos_EmbeddedFont", "Aptos_MSFontService", Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0); margin-left: 15px;">
<b>Submissions accepted for any dataset until June 13, 2026</b></li></ul>
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