[3dem] Postdoctoral position in Structural biology at the University of Dundee, Scotland

[Peter Cossar (Staff)]

Postdoctoral Research Assistant - CeTPD - UOD1992

online posting: https://urldefense.com/v3/__https://www.dundee.ac.uk/work-for-us/jobs/uod1992__;!!Mih3wA!A3kjVsgYteR-Al8hWutc3LafqdAtNT9duFFap92rYP85_grYWNUIaRoFpwZoDd0qp-E59DZCvjtjfp4HSNfj_ao74JM$ 

The Opportunity
This is an outstanding opportunity to join a recently established Research Centre that is pioneering new models of translational chemical biology and advancing the frontiers of molecular glue research. You will gain experience in world-leading, collaborative, and high-impact research at the forefront of drug discovery, with access to strong academic and industrial partnerships. We are seeking a highly motivated Postdoctoral Researcher in Structural and/or Chemical Biology to join the research group of Dr Peter Cossar at the Centre for Targeted Protein Degradation (CeTPD), University of Dundee.

About the role
The Cossar Lab integrates molecular biophysics, structural biology, and organic synthesis to develop chemical tools that address key questions in proximity-induced drug discovery, with a focus on targeting intrinsically disordered protein complexes. This Royal Society-funded position focuses on identifying molecular glues that stabilise disease-relevant protein complexes involved in Motor Neuron Disease (MND) and Frontotemporal Dementia (FTD). The position is available from the 1st of October 2025, and for a fixed-term of 3 years, though I am happy to delay the start by 4–5 months for the right candidate.

Who we are looking for
Familiarity with either one of the two techniques

  *   Protein mass spectrometry for chemical biology and biophysics (strong preference for native MS)
  *   Protein-ligand structural biology (X-ray or cryo-EM) including structure-refinement tools (e.g., CCP4, PHENIX, Coot, DIALS, Cryo-Spark, Relion)
  *   Experienced with biophysical assay design and troubleshooting
  *   Experience with studying protein-ligand interactions and structure-based drug design
  *   Cloning and DNA construct design is a plus
  *   Experienced with bacterial, insect and/or human recombinant protein expression systems

What we offer
    • Fully funded 3-year PhD with competitive salary
    • Access to state-of-the-art facilities (ThermoFisher Glacios 200kV X-FEG cryogenic transmission electron microscope (CryoTEM; https://urldefense.com/v3/__https://www.dundee.ac.uk/locations/cryo-electron-microscopy__;!!Mih3wA!A3kjVsgYteR-Al8hWutc3LafqdAtNT9duFFap92rYP85_grYWNUIaRoFpwZoDd0qp-E59DZCvjtjfp4HSNfjSW6C5rk$ ), X-ray beamlines, electron Bio‑Imaging Centre    (eBIC; https://urldefense.com/v3/__https://www.diamond.ac.uk/industry/Techniques-Available/Integrated-Structural-Biology/Biological-Sciences-Electron-Microscopy/__;!!Mih3wA!A3kjVsgYteR-Al8hWutc3LafqdAtNT9duFFap92rYP85_grYWNUIaRoFpwZoDd0qp-E59DZCvjtjfp4HSNfjTXZvL68$ ), and  biophysical instruments
    • Supportive, collaborative, and interdisciplinary environment
    • Collegial culture valuing equality, work-life balance, and regular social events

How to apply
Please apply via the Dundee online application. Candidates are also encouraged to email Dr Peter Cossar (pcossar001 at dundee.ac.uk<mailto:pcossar001 at dundee.ac.uk> ) by Monday, 6 October 2025

Questions?
Feel free to contact Dr Peter Cossar (pcossar001 at dundee.ac.uk<mailto:pcossar001 at dundee.ac.uk> )


Dr Peter Cossar
Principal Investigator
School of Life Sciences, University of Dundee,
1 James Lindsay Place, Dundee, DD1 5JJ
PCossar001 at dundee.ac.uk<mailto:PCossar001 at dundee.ac.uk>
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The University of Dundee is a registered Scottish Charity, No: SC015096
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