[3dem] Postdoctoral Position in Cryo-Electron Tomography and Host-Pathogen Interactions

[Shiwei Zhu]

Dear All,


Dr. Shiwei Zhu's laboratory (https://urldefense.com/v3/__https://www.shiweizhulab.org/__;!!Mih3wA!AWKI-OAX1jTSLR8R3o62r2do8jH8bJ-w7gEEiyoSLHR6LbR0gY2BrFELr1ureYCxt0WU6EXkY8YtM80qew$ ) in the
Department of Physiology and Biophysics at Case Western Reserve University
in Cleveland, Ohio, is seeking applications for an immediate postdoctoral
position to investigate host defense mechanisms and pathogen adaptation
within host cells using cutting-edge cryo-electron microscopy techniques.



Our lab has pioneered in vitro reconstitution systems to study
host-pathogen interactions using cryo-ET (Science, 2024, PMID: 38422126)
and cryo-EM (Science, 2021, PMID: 34437126). Building on this foundation,
we are expanding our research to visualize crucial biological processes
that defend host cells against external threats in vivo. The successful
candidate will utilize cryo-ET and the Aquilos-2 cryo-FIB/SEM integrated
with an internal cryo-correlative light electron microscopy (cryo-CLEM) to
advance these investigations. Our lab is also actively engaged in cryo-ET
method development with particular emphasis on high-throughput sample
preparation (BioRxiv, 2025, PMID: 39990359).



The postdoctoral fellow will develop imaging pipelines for high-throughput
in situ cryo-ET and apply these methods to studying host-pathogen
interactions. Additional responsibilities include reconstituting functional
antimicrobial complexes, determining their structures using cryo-EM/ET, and
designing structure-based experiments to elucidate the molecular mechanisms
underlying antimicrobial defense. The position offers access to
state-of-the-art facilities through the CWRU cryo-EM core, including a
Glacios TEM for sample screening, Titan Krios microscopes for cryo-ET data
collection, as well as full access to cryo-FIB/SEM and cryo-CLEM
instrumentation for in situ studies.



Applicants should possess a Ph.D. or equivalent degree in structural
biology, biochemistry, biophysics, microbiology, cell biology, or a related
field. Prior experience in structural biology is beneficial but not
required. To apply, please email Dr. Shiwei Zhu (shiwei.zhu at case.edu) with
a cover letter describing your research interests and career goals, a
current CV, and contact information for two academic references.


Best wishes,

Shiwei Zhu

Shiwei Zhu,  Ph.D.
Assistant Professor,
Department of Physiology and Biophysics
Case Western Reserve University
School of Medicine, Robbins Building E621
Email: shiwei.zhu at case.edu
https://urldefense.com/v3/__https://www.shiweizhulab.org__;!!Mih3wA!AWKI-OAX1jTSLR8R3o62r2do8jH8bJ-w7gEEiyoSLHR6LbR0gY2BrFELr1ureYCxt0WU6EXkY8Z6blh1aQ$ 
https://urldefense.com/v3/__https://physiology.case.edu/people/faculty/shiwei-zhu__;!!Mih3wA!AWKI-OAX1jTSLR8R3o62r2do8jH8bJ-w7gEEiyoSLHR6LbR0gY2BrFELr1ureYCxt0WU6EXkY8ZLKNxIZw$ 
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