[3dem] Postdoc at MRC-LMB, Cambridge UK

[Suyang Zhang]

Dear all,

We are looking for an enthusiastic postdoc to join our team to investigate the mechanism of transcription-coupled splicing. The project aims to understand the crosstalk between the transcription and splicing machineries using a combined biochemical and structural approach with a focus on cryo-EM. 

In eukaryotes, RNA synthesis and splicing are intricately coupled to each other to enhance the efficiency and accuracy of pre-mRNA processing. Despite advances in our understanding of transcription and splicing as two separate processes, the molecular mechanisms underlying co-transcriptional splicing in a cellular context remain to be elucidated. We have previously determined the structure of a transcribing Pol II-U1 snRNP complex that provided a model of how distant intron ends can be functionally paired for splicing. Recently, we have defined the mechanism of how transcription speed is regulated during productive elongation, shedding light on how Pol II speed may change across introns and exons. For further information, please visit: https://urldefense.com/v3/__https://www2.mrc-lmb.cam.ac.uk/groups/zhang/__;!!Mih3wA!E2rQn8qXByfEkDUM4HbnktCvVVoDkNHhgOqEASGzMBdm45htY5OpYP23mWTT74SY0M-sxJWgsYl1h2O9padzpEhV9Q$ 

Informal enquires are welcomed and can be sent directly to szhang at mrc-lmb.cam.ac.uk

Apply here: https://urldefense.com/v3/__https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/2575-Postdoctoral-Scientist-Structural-Studies-Dr-Suyang-Zhang-LMB-2575/en-GB__;!!Mih3wA!E2rQn8qXByfEkDUM4HbnktCvVVoDkNHhgOqEASGzMBdm45htY5OpYP23mWTT74SY0M-sxJWgsYl1h2O9padH384_YA$ 

Closing date: 21st April

Best wishes,
Suyang

Suyang Zhang
MRC Laboratory of Molecular Biology
Francis Crick Avenue, Cambridge Biomedical Campus
Cambridge CB2 0QH, U.K.
tel: +44 (0)1223 267077
https://urldefense.com/v3/__https://www2.mrc-lmb.cam.ac.uk/groups/zhang/__;!!Mih3wA!E2rQn8qXByfEkDUM4HbnktCvVVoDkNHhgOqEASGzMBdm45htY5OpYP23mWTT74SY0M-sxJWgsYl1h2O9padzpEhV9Q$ 

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