<html><head><meta http-equiv="content-type" content="text/html; charset=us-ascii"></head><body style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;">Dear all,<br><br>We are looking for an enthusiastic postdoc to join our team to investigate the mechanism of transcription-coupled splicing. The project aims to understand the crosstalk between the transcription and splicing machineries using a combined biochemical and structural approach with a focus on cryo-EM. <br><br>In eukaryotes, RNA synthesis and splicing are intricately coupled to each other to enhance the efficiency and accuracy of pre-mRNA processing. Despite advances in our understanding of transcription and splicing as two separate processes, the molecular mechanisms underlying co-transcriptional splicing in a cellular context remain to be elucidated. We have previously determined the structure of a transcribing Pol II-U1 snRNP complex that provided a model of how distant intron ends can be functionally paired for splicing. Recently, we have defined the mechanism of how transcription speed is regulated during productive elongation, shedding light on how Pol II speed may change across introns and exons. <span style="font-size: 9pt; line-height: 13.8px; font-family: Arial, sans-serif;">For further information, please visit: <a href="https://urldefense.com/v3/__https://www2.mrc-lmb.cam.ac.uk/groups/zhang/__;!!Mih3wA!E2rQn8qXByfEkDUM4HbnktCvVVoDkNHhgOqEASGzMBdm45htY5OpYP23mWTT74SY0M-sxJWgsYl1h2O9padzpEhV9Q$">https://www2.mrc-lmb.cam.ac.uk/groups/zhang/</a></span><div><span style="font-size: medium;"></span><font face="Arial, sans-serif"><br></font>Informal enquires are welcomed and can be sent directly to szhang@mrc-lmb.cam.ac.uk<br><br>Apply here: <a href="https://urldefense.com/v3/__https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/2575-Postdoctoral-Scientist-Structural-Studies-Dr-Suyang-Zhang-LMB-2575/en-GB__;!!Mih3wA!E2rQn8qXByfEkDUM4HbnktCvVVoDkNHhgOqEASGzMBdm45htY5OpYP23mWTT74SY0M-sxJWgsYl1h2O9padH384_YA$">https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/2575-Postdoctoral-Scientist-Structural-Studies-Dr-Suyang-Zhang-LMB-2575/en-GB</a><div><div><br></div><div>Closing date: 21st April<br><div><br><div>Best wishes,<br>Suyang</div></div></div></div></div><div><br></div><div>
<meta charset="UTF-8"><div>Suyang Zhang<br>MRC Laboratory of Molecular Biology<br>Francis Crick Avenue, Cambridge Biomedical Campus<br>Cambridge CB2 0QH, U.K.<br>tel: +44 (0)1223 267077<br><a href="https://urldefense.com/v3/__https://www2.mrc-lmb.cam.ac.uk/groups/zhang/__;!!Mih3wA!E2rQn8qXByfEkDUM4HbnktCvVVoDkNHhgOqEASGzMBdm45htY5OpYP23mWTT74SY0M-sxJWgsYl1h2O9padzpEhV9Q$">https://www2.mrc-lmb.cam.ac.uk/groups/zhang/</a></div>
</div>
<br></body></html>