[3dem] THE EIGHTH BRAZIL SCHOOL FOR SINGLE PARTICLE CRYO-EM (27 Sept - 9 Oct 2018)

[Marin van Heel]

FIRST ANNOUNCEMENT:

  ---   THE EIGHTH BRAZIL SCHOOL FOR SINGLE PARTICLE CRYO-EM   ---

To be held in Mariporã, SP Brazil 27 Sept - 9 Oct 2018, 
(www.brazil-school.org <http://www.brazil-school.org>)

Our single-particle school is a unique and intensive 12-day hands-on 
course/workshop, in which theory and practice are tightly intertwined.
The understanding of the principles of cryo-EM data processing stands 
central in this event and a few cryo-EM pioneers will explain the 
approaches to the participants to a level where they can apply it 
themselves.
The spectrum of topics covered suits attendees who are new to the field 
as well as those for whom the technique is of growing importance and who 
wish to acquire an in-depth understanding of the fundamental principles.

The final days of the meeting will be devoted to advanced topics such as 
high-resolution refinements and the processing of heterogeneous data 
sets ("4D cryo–EM”). Advanced topics will include:

1)Optimizing data collection with direct electrons detectors and 
exploiting movies.
2)Full data set automatic CTF correction.
3)Correction of anisotropic magnification.
4)Reaching atomic resolution without reference bias: 
alignment-by-classification (ABC-4D) refinement procedures.
5)Unbiased "Random Startup" of 3D and 4D reconstructions.
6)4D refinement procedures for high-resolution results using IMAGIC and 
Frealign/cisTEM.
7)Fitting and refining atomic coordinates in high-resolution cryo-EM 
maps (~4Å or better) using programs such as REFMAC and Coot.
8)Validation of final results by reproducible resolution criteria.

Kind regards,

Marin van Heel

PS: We have experienced a very strong interest in the 8th Brazil school 
even prior to this formal announcement!
The school is likely to be oversubscribed so don't delay your registration.

-- 
==============================================================

     Prof Dr Ir Marin van Heel

     Laboratório Nacional de Nanotecnologia - LNNano
     CNPEM/LNNano, Campinas, Brazil

     tel:    +55-19-3518-2316
     mobile  +55-19-981809332
                  (041-19-981809332 TIM)
     Skype:  Marin.van.Heel
     email:  marin.vanheel(A_T)gmail.com
             marin.vanheel(A_T)lnnano.cnpem.br
     and:    mvh.office(A_T)gmail.com

--------------------------------------------------
     Emeritus Professor of Cryo-EM Data Processing
     Leiden University
     Mobile NL: +31(0)652736618 (ALWAYS ACTIVE SMS)
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     Emeritus Professor of Structural Biology
     Imperial College London
     Faculty of Natural Sciences
     email: m.vanheel(A_T)imperial.ac.uk
--------------------------------------------------

I receive many emails per day and, although I try,
there is no guarantee that I will actually read each incoming email.

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