[3dem] ESRF-SANOFI joint PhD position in cryo EM; Grenoble France
guy schoehn
guy.schoehn at ibs.fr
Fri Jun 2 04:22:05 PDT 2017
Dear all,
Please find bellow the description of a joint PhD position in CryoEM
between ESRF and SANOFI
Best regards
Guy Schoehn
PhD thesis title: High resolution Cryo- Electron Microscopy of Antibody
/ Antigen complexes
More and more research focus is being put on biologics and their
development as drugs. These molecules are usually large and flexible and
they can interact with various targets located on the surface of cells;
Bi-specific antibodies are an example that can potentially bind to two
different antigens and which have gained attention due to their
potential application in cancer immunotherapy and drug delivery. To
fully understand their mechanism, structural knowledge at an atomic
level is needed.
While low resolution studies can be obtained using traditional
microscopy, high resolution studies of these interactions are usually
performed by protein crystallography (or by Hydrogen Deuterium Exchange
studies) using fragments of both antibody and antigen. The ESRF is in
progress of installing a Krios microscope which, coupled with a direct
electron detector and a Volta phase plate will enable us to determine
the full structure of the complexes.
The successful candidatewill characterise Ag/Biologics complexes from
Sanofi, using state-of-the-art microscopes at the cryo-EM platform of
the Partnership for Structural Biology (PSB) and will determine the
high-resolution structure of one or more of these complexes.
The PhD thesis will last 3 years starting in late autumn 2017, in a
collaboration between Sanofi (Vitry sur Seine, France) and the ESRF
(Grenoble, France) under the co-supervision of Dr. Magali Mathieu
(Sanofi) and Dr. Gordon Leonard (ESRF). This thesis will be CIFRE
(Conventions Industrielles de Formation par la REcherche) and the
student will be a Sanofi employee (CDD) for the whole duration of the
thesis. Most of his/her work will be performed at the ESRF.
The applicant must have a Master Degree (Master2 or MSc) in integrated
structural biology or biophysics, some knowledge in cryo-electron
microscopy and in molecular and cell biology. He/she should be a team
player and have good communication skills.
CV and accompanying letter should be sent to magali.mathieu at sanofi.com
<mailto:magali.mathieu at sanofi.com>AND
christoph.mueller_dieckmann at esrf.fr
<mailto:christoph.mueller_dieckmann at esrf.fr>before July 7, 2017.
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