[3dem] AZ/RFI Postdoctoral Fellow - In situ structural biology of SARM1

[Kasim Sader]

Dear 3DEM members,

Do you have expertise in, and passion for, cryo-EM and in situ structural
biology? We are looking for an enthusiastic, talented individual who would
like to advance our understanding of the molecular mechanisms of
neurodegeneration inside cells and tissues, melding the expertise of
AstraZeneca and the Rosalind Franklin Institute. This partnership joins up
a company that turns ideas into life changing medicines with an Institute
pushing forward the boundaries of science and technology. You will work at
the leading edge of structural biology, with nascent technologies, to
decipher the molecular mechanism of structures inside cells.

Understanding molecular complexity is crucial to productive drug discovery
and efficacious treatments. For many therapeutic targets we can learn a
tremendous amount of detailed molecular information on purified samples
through structural and biophysical techniques. However, these targets
physiologically operate in the complex environment of cells and tissues. We
need to extend our understanding of intracellular processes on the
molecular scale so we can better address gaps in understanding, and someday
do structure based drug design in situ.

Access to 2 PFIBs, a Titan Krios, and cryo CLEM including confocal at RFI,
AstraZeneca’s in-house Titan Krios, and the 2 Krios at the Cambridge
Pharmaceutical Cryo-EM Consortium will be available.

See the full job ad at:

https://urldefense.com/v3/__https://astrazeneca.wd3.myworkdayjobs.com/Careers/job/UK---Cambridge/Postdoctoral-Fellow---In-situ-structural-biology-of-SARM1_R-208307-1__;!!Mih3wA!GJMLpJ3Cw0W8lrUFSOLoS7RvmPmKCvkSkV6gf73F8Y2bOCWndETrhHv0gCK3mLVA1qJZFxSGypeWkcCeE4LpSA0$ 

For further information, please contact me (
kasimstefan.sader at astrazeneca.com), or  Michael Grange (
michael.grange at rfi.ac.uk).

Best regards,
Kasim
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